BioCentury | Apr 11, 2020
Translation in Brief

ILIAS Biologics’ exosomes for sepsis; plus regulating cocaine seeking and a new COVID-19 target

Relieving sepsis-related organ damage  An ILIAS Biologics Inc. and Korea Advanced Institute of Science and Technology team described in Science Advances a sepsis treatment comprising exosomes loaded with a “super repressor” NF-κB inhibitor: a dominant...
BC Innovations | Oct 4, 2018
Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Bioinformatics screens; cellular assays; gene profiling A single-cell, sequencing-based method that correlates RNA expression with chromatin accessibility could help identify biomarkers of cellular activity and/or cell type. The method involves: distributing extracted cell nuclei...
BC Innovations | Mar 27, 2014
Targets & Mechanisms

Insights into ependymoma

Two independent studies have illuminated the fine molecular details of ependymoma tumors and identified targets for a previously intractable disease. A St. Jude Children's Research Hospital team focused on forebrain ependymomas and identified a fusion...
BC Week In Review | Nov 25, 2013
Clinical News

Revalesio preclinical data

In a mouse model of PD, RNS60 restored dopamine loss, preserved motor function and provided significant protection against neuronal death through upregulation of the nuclear factor of kappa light polypeptide gene enhancer in B cells...
BioCentury | Jan 16, 2012
Emerging Company Profile

Rel-MD: Blocking two paths

Most inhibitors of NF-kappa B activation on the market and in development target only the better known of two pathways. Rel-MD Inc. thinks the lesser-known pathway actually plays a more important role in disease and...
BC Innovations | Aug 26, 2010
Distillery Techniques

Technology: Disease models

This week in techniques Approach Summary Licensing status Publication and contact information Disease models Mice expressing mutant nuclear factor of k light polypeptide gene enhancer in B-cells inhibitor-a ^NFKBIA; IKBA) as models of Sjögren's syndrome...
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