BioCentury | Nov 25, 2020
Product Development

Friedreich’s ataxia program hits FDA snag, denting Reata’s shares

...Nuclear factor of κ light polypeptide gene enhancer in B cells 1 NRF2 (NFE2L2) - Nuclear factor (erythroid-derived 2)-like 2 Paul...
BioCentury | Nov 10, 2020
Product Development

Reata, Calliditas make good on renewed interest in kidney disease with Phase III successes

...results suggest the novel mechanism of action, NRF2...
...Part A to prove long-term renal protection.TARGETSNRF2 (NFE2L2...
BioCentury | Jul 31, 2020
Product Development

U.K. locks down access to recombinant protein vaccine via GSK, Sanofi deal, its fourth for COVID-19

...all hospitalized patients and up to 72% of those who do not survive COVID-19. The NFE2L2...
...of $1.3 billion. Targets IFNα - Interferon α IFNλ - Interferon λ NFE2L2 (NRF2) - Nuclear factor (erythroid-derived 2)-like 2 Elizabeth...
BioCentury | Jun 12, 2020
Deals

Reata rebound

...and autosomal dominant polycystic kidney disease 10/10/19 - Reacquires rights to bardoxolone, omaveloxolone and next-generation Nrf2...
...has stretched across a decade. Abbott Laboratories (NYSE:ABT) paid $450 million up front for the NFE2L2...
...2011, and doubled down later that year, paying $400 million up front for Reata’s remaining NFE2L2...
BioCentury | Mar 14, 2020
Translation in Brief

A peptide fusion blocker for multiple coronaviruses, the cryo-EM structure of SARS-CoV-2 main protease, plus Locus, Excision and Harvard-Dana-Farber

...a proof-of-concept experiment two compounds that displaced a KEAP1-binding peptide derived from the transcription factor NFE2L2...
...proteinase Cas3 - CRISPR-associated helicase Cas3 KEAP1 - Kelch-like ECH-associated protein 1 NFE2L2 (NRF2) - Nuclear factor (erythroid-derived 2)-like 2 BioCentury...
BioCentury | Feb 1, 2020
Finance

Reata rises on renal interest from Amgen

...business development opportunities there.” Reata Pharmaceuticals Inc. (NASDAQ:RETA) regained rights to its first- and second-generation NFE2L2...
BioCentury | Nov 15, 2019
Financial News

Despite flurry of deals, follow-ons well short of 2018’s total

...proposed to raise 2 million shares Tuesday after reporting positive data for bardoxolone. The first-generation NFE2L2...
...III Oncology Miss” ). Halozyme was up $0.82 to $18.49 Thursday. Targets: NFE2L2 (NRF2) - Nuclear factor (erythroid-derived 2)-like 2...
BioCentury | Nov 13, 2019
Clinical News

Bardoxolone data set Reata up to advance second compound toward registration

...registrational data in follow-on indications. On Tuesday, Reata Pharmaceuticals Inc. (NASDAQ:RETA) said bardoxolone, its first-generation NFE2L2...
...kidney disease (CKD) caused by Alport syndrome. The company regained rights to bardoxolone and second-generation NFE2L2...
...MicroRNA-21; NEF2L2 (NRF2) - Nuclear factor (erythroid-derived 2)-like 2 Sandi Wong, Staff Writer bardoxolone methyl (RTA 402, CDDO-Me) Reata Pharmaceuticals Inc. Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) (NRF2) Alport...
BioCentury | Oct 14, 2019
Clinical News

Reata’s pivotal data in Friedreich ataxia point to submissions

...points higher than with placebo (p=0.034). Reata also said the second-generation activator of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NRF2...
...The company reacquired rights from AbbVie Inc. (NYSE:ABBV) on Friday to its portfolio of second-generation NFE2L2...
...up $4.78 to $100.59 during Monday’s regular trading session. Sandi Wong, Staff Writer Reata Pharmaceuticals Inc. Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) (NRF2) Friedreich...
BioCentury | Oct 10, 2019
Company News

On eve of pivotal data, Reata pays AbbVie $330M to regain cardiorenal candidates

...having turned away from cardiovascular and renal indications, Reata reacquired rights to bardoxolone and second-generation NRF2...
...Reata will pay AbbVie the first $75 million this year for the NRF2 (nuclear factor (erythroid-derived 2)-like 2; NFE2L2...
...to $74.45 on Thursday. Sandi Wong, Staff Writer bardoxolone methyl (RTA 402, CDDO-Me) AbbVie Inc. Reata Pharmaceuticals Inc. Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) (NRF2) chronic...
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