BioCentury | Oct 11, 2018
Distillery Therapeutics

Cancer

...Melanoma Cell culture and mouse studies identified an inhibitor of the transmembrane domain of p75 NTR...
...expressing the human transmembrane domain of p75 NTR yielded a chalcone-flavonoid compound that inhibited p75 NTR’s...
...include testing the compound in additional animal models of melanoma. TARGET/MARKER/PATHWAY: p75 neurotrophin receptor (p75 NTR...
BioCentury | May 29, 2018
Company News

Priority Review for Loxo's larotrectinib in tissue-agnostic indication

FDA accepted and granted Priority Review to an NDA for larotrectinib (LOXO-101) from Loxo Oncology Inc. (NASDAQ:LOXO) to treat locally advanced or metastatic solid tumors with neurotrophic tyrosine kinase receptor (Trk) fusion proteins, regardless of...
BioCentury | Sep 15, 2017
Clinical News

Levicept begins Phase I of fusion protein for chronic pain

...safety and neurological assessments, as well as pharmacokinetics. LEVI-04 is a p75 neurotrophin receptor (p75 NTR...
...Neurology Molecular target: p75 neurotrophin receptor (p75 NTR) ; Nerve growth factor (NGF) Description: p75 NTR...
...Phase I started Milestone: NA Elizabeth S. Eaton LEVI-04 p75NTR-Fc Levicept Ltd. Pfizer Inc. Nerve growth factor (NGF) p75 neurotrophin receptor (p75 NTR...
BioCentury | Sep 14, 2017
Clinical News

Levicept begins Phase I of fusion protein for chronic pain

...pain due to osteoarthritis (OA) of the knee. LEVI-04 is a p75 neurotrophin receptor (p75 NTR...
BioCentury | Sep 29, 2016
Distillery Therapeutics

Therapeutics: p75 neurotrophin receptor (p75 NTR); nerve growth factor (NGF)

...Ophthalmic disease INDICATION: Diabetic retinopathy; ophthalmic Mouse studies suggest inhibiting p75 NTR or the precursor form...
...types of retinopathy. In a mouse model of diabetic retinopathy, intravitreal injection of a p75 NTR...
...identifying other inhibitors of p75 NTR in models of diabetic retinopathy. Sanofi has the p75 NTR...
BioCentury | Jun 16, 2016
Distillery Therapeutics

Therapeutics: Forkhead box A1 (FOXA1); FOXA2; FOXA3; GATA binding protein 4 (GATA4); HNF1 homeobox A (HNF1A); hepatocyte nuclear factor 4 α (HNF4A; TCF) FOXA3,

...liver fibrosis, in vivo transduction of myofibroblasts with a single p75 neurotrophin receptor ( p75 NTR...
BioCentury | Feb 8, 2016
Finance

Asset renaissance

...associated with osteoarthritis. The compound is in preclinical development and comprises p75 neurotrophin receptor (p75 NTR...
BioCentury | Jan 21, 2016
Distillery Techniques

Techniques: Engineered diatom-based biosilica particles for delivery of chemotherapeutics

...cell line, nanoparticles labeled with an antibody against the cell surface p75 neurotrophin receptor (p75 NTR...
BioCentury | Oct 8, 2014
Financial News

Levicept raises L10M series A

...development to treat chronic pain associated with osteoarthritis. The compound comprises p75 neurotrophin receptor (p75 NTR...
BioCentury | Sep 15, 2014
Emerging Company Profile

Levicept: Modulating NGF

...pain while also avoiding the side effects. p75NTR-Fc is a soluble p75 neurotrophin receptor (p75 NTR...
...18-20 (Sept. 1, 2014) Sidebars Levicept Ltd. Sandwich, U.K. Technology: Soluble p75 neurotrophin receptor (p75 NTR...
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