19:31 , Aug 8, 2019 |  BC Innovations  |  Distillery Therapeutics

Activating WNT signaling to regenerate aged or damaged intestinal epithelium

DISEASE CATEGORY: Gastrointestinal INDICATION: Gastrointestinal Increasing WNT signaling through NOTUM inhibition or WNT3A supplementation could promote the regeneration of aged or damaged intestinal epithelia. Expression levels of the extracellular WNT inhibitor NOTUM were higher in...
08:00 , Mar 5, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Notum pectinacetylesterase homolog (NOTUM); wingless-type MMTV integration site (WNT) Patent and licensing status unavailable

Cancer INDICATION: Cancer In vitro and in vivo studies suggest NOTUM could help treat WNT-driven cancers. In fruit flies, overexpression of fly NOTUM suppressed the expression of a gene activated by high levels of WNT...