BioCentury | Jan 31, 2020
Distillery Therapeutics

Supplementation with for alcoholic fatty liver disease

DISEASE CATEGORY: Hepatic INDICATION: Liver disease Oral administration of the gut microbe Roseburia intestinalis could treat alcoholic fatty liver disease. In 22 patients with alcoholic liver disease, lower abundances of Roseburia spp. in fecal samples...
BC Innovations | Dec 19, 2019
Distillery Therapeutics

Inhibiting the EIF4G1-EIF4E interaction to treat autism

DISEASE CATEGORY: Neurology INDICATION: Autism Disrupting the EIF4G1-EIF4E interaction could treat autism, a disorder characterized by social deficits and associated with increased dendritic spine densities and mutations in the E3 ligase complex component CUL3. In...
BC Innovations | Nov 22, 2019
Distillery Therapeutics

Engineered ECM scaffolds to facilitate muscle, nerve and vascular regeneration

DISEASE CATEGORY: Transplant INDICATION: Tissue replacement Engineered polymer-based extracellular matrix (ECM) scaffolds could improve tissue regeneration after transplantation or injury. The method involves fabricating membranous or tubular templates out of synthetic polymers, implanting the templates...
BC Innovations | Oct 8, 2019
Distillery Therapeutics

Novel targets induce cardiomyocyte regeneration

DISEASE CATEGORY: Cardiovascular INDICATION: Myocardial infarction (MI) Gene therapies delivering CCL24 or IGF2BP3 could restore cardiac function following MI. RNA-seq analysis identified 874 genes including CCL24 and IGF2BP3 that were upregulated in mouse heart tissue...
BC Innovations | Aug 29, 2019
Distillery Therapeutics

Platelet transfusions for sepsis

DISEASE CATEGORY: Infectious disease INDICATION: Sepsis Platelet transfusions could treat sepsis by inducing monocytes to mature into proinflammatory macrophages. When co-cultured with platelets, activated monocytes were more likely to differentiate to M1 macrophages with proinflammatory...
BC Innovations | Aug 29, 2019
Distillery Techniques

STAT3-based gene signature to predict response to glioblastoma targeted therapy

TECHNIQUES CATEGORY: Biomarkers TECHNOLOGY: Gene profiling A STAT3-based gene expression signature could identify glioblastoma multiforme (GBM) patients that will respond to STAT3 inhibitors as monotherapies or in combination with IGF1R (insulin-like growth factor-1 receptor; CD221)...
BC Innovations | Aug 29, 2019
Distillery Techniques

The E3 ligase CHIP as an Alzheimer's disease biomarker

TECHNIQUES CATEGORY: Biomarkers TECHNOLOGY: Tissue markers; gene profiling Hippocampal expression levels of CHIP, an E3 ubiquition ligase, could serve as a biomarker of AD severity. High levels of a tau (microtubule-associated protein tau; MAPT; FTDP-17)...
BC Innovations | Aug 29, 2019
Distillery Therapeutics

Bacterial therapy for food allergy

DISEASE CATEGORY: Inflammation INDICATION: Allergy A team led by ConsortiaTX Inc. co-founders showed that oral administration of gut commensal bacteria could treat and prevent food allergy. Of 77 species with either higher or lower fecal...
BC Innovations | Aug 23, 2019
Distillery Techniques

Mouse model for sensitive detection of AAV tissue tropism and gene expression

TECHNIQUES CATEGORY: Disease models TECHNOLOGY: Animal models A mouse model developed in the lab of Spark Therapeutics Inc. co-founder Beverly Davidson could help guide AAV design by sensitively mapping the tissues where AAV vectors are...
BC Innovations | Aug 23, 2019
Distillery Therapeutics

Hydrogels with montmorillonite could repair bone defects

DISEASE CATEGORY: Musculoskeletal INDICATION: Bone repair Delivering the clay mineral montmorillonite, which could serve as a scaffold for cells, as part of a nanocomposite hydrogel could treat bone defects. The nanocomposite hydrogels are synthesized by...
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