BioCentury | Jul 30, 2015

Neglected Attention

Although the Drugs for Neglected Diseases initiative (DNDi) has made good on its 2003 promise to develop six therapies within 12 years, the not-for-profit wants to quicken the pace of progress for treatments that aren't...
BioCentury | Nov 5, 2009
Targets & Mechanisms

Norrin vs. VEGF

...Hopkins University School of Medicine , establishes how a secreted proangiogenic protein called Norrie disease pseudoglioma ( NDP...
BioCentury | Nov 5, 2009
Distillery Therapeutics

Indication: Ophthalmic disease

...Various indications Frizzled homolog 4 (FZD4); Norrie disease pseudoglioma (NDP; Norrin) Studies in mice suggest that antagonizing NDP... the vascular endothelium had visual defects and poorly vascularized retinas compared with wild-type controls. Ndp... those in the Fzd4 knockout mice. Next steps include testing the effects of blocking NDP...
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