13:21 , May 31, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: 3-D models Mouse intestinal organoids could be used to model intestinal drug metabolism and toxicity. The organoids were generated by treating primary mouse crypt cells isolated from the small intestine with a cocktail of...
00:53 , Jan 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Dermatology

INDICATION: Scars / wrinkles Mouse and patient sample studies suggest BMP2 or BMP4 could help prevent or treat scars. Under culture conditions that promote adipocyte differentiation, dermal cells of wild-type mice taken from wounds containing...
08:00 , Feb 18, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Bone morphogenetic protein 2 (BMP2)

Cancer INDICATION: Ovarian cancer In vitro, patient sample and mouse studies suggest inhibiting BMP2 could help treat ovarian cancer. In human ovarian cancer cell lines and tumor samples from patients with ovarian cancer, BMP2 increased...
07:00 , Apr 24, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Musculoskeletal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Bone repair; osteoporosis Hypoxia-inducible factor 1a (HIF1A; HIF1a); notch 1 (NOTCH1) Mouse studies suggest stimulating expansion of a vascular endothelial vessel subtype in bone...
07:00 , Oct 24, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms In vivo reprogramming of astrocytes to neuroblasts Mouse studies suggest proliferating neuroblasts generated in vivo from reprogrammed astrocytes could help treat...
07:00 , Jul 11, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Huntington's disease (HD) Brain-derived neurotrophic factor (BDNF); noggin (NOG) Rodent and primate studies suggest overexpression of BDNF and NOG could help treat HD. In a...
07:00 , Sep 1, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Bone morphogenetic protein 4 (BMP4); noggin (NOG) Patient and rabbit studies suggest inhibiting BMP signaling could help treat intraventricular hemorrhage in premature infants. In...
07:00 , Apr 14, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Multiple sclerosis (MS) Bone morphogenetic protein 4 (BMP4) A study in mice suggests that antagonizing BMP4 could help treat MS. In a mouse model...