07:00 , Oct 27, 2016 |  BC Innovations  |  Distillery Techniques

Drug platforms

TECHNOLOGY: Structural analyses Chimeric rat-human NMDA receptors could help guide the development of selective NMDA receptor PAMs for neurological diseases. The chimeric receptors were constructed by replacing the transmembrane or ligand-binding domains of various NMDA receptor...
07:00 , Aug 25, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: NMDA receptor NR1 subtype (GRIN1; NR1)

Autoimmune disease INDICATION: Multiple sclerosis (MS) In vitro and mouse studies suggest antagonizing GRIN1 could help treat MS. In an in vitro assay of inflammation-associated blood-brain barrier (BBB) permeability, an anti-GRIN1 mAb decreased monocyte migration and leukocyte...
07:00 , Oct 3, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Epilepsy NMDA receptor NR1 subtype (GRIN1; NR1); GRIN2B (NR2B); GABAA receptor a1 (GABRA1); GABAA receptor b3 (GABRB3) ...
07:00 , Sep 5, 2013 |  BC Innovations  |  Targets & Mechanisms

Epilepsy narrows down

A spate of human genetic studies has shed light on the root causes of idiopathic focal epilepsy, a common childhood form of the disease. The studies suggest that a group of epilepsies and encephalopathies marked...
07:00 , Mar 15, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Cognitive dysfunction AMPA 1 glutamate receptor (GRIA1; GLUR1); NMDA receptor NR1 subtype (GRIN1; NR1); proteasome Rat studies...
07:00 , Mar 28, 2011 |  BC Week In Review  |  Clinical News

Prana preclinical data

In a transgenic mouse model of AD, daily 30 mg/kg oral PBT2 for 11 days significantly increased hippocampal dendritic spine density in both young and old mice vs. controls (p<0.001 for both). PBT2 also significantly...
07:00 , Oct 1, 2009 |  BC Innovations  |  Distillery Techniques

Technology: Disease models

Approach Summary Licensing status Publication and contact information Disease models Mouse model of schizophrenia Mice with a...