BioCentury | May 5, 2016
Distillery Therapeutics

Therapeutics: NLR family apoptosis inhibitory protein 1 (NAIP1); NAIP2; NAIP5

...Gram-negative bacterial infection; sepsis Cell culture and mouse studies suggest inhibiting NAIP1 , NAIP2 or NAIP5...
...NAIP5 decreased lethal inflammasome activity and cell death compared with normal expression of NAIP2 and NAIP5...
...of lethal B. thailandensis-, E. coli- and Pseudomonas aeruginosa-induced sepsis, knockout of NAIP1, NAIP2 or NAIP5...
BioCentury | Jun 23, 2008
Company News

GlycoMar, Verona Pharma deal

Verona and GlycoMar will identify preclinical candidates for respiratory indications including asthma and hay fever. The partners will advance compounds from GlycoMar’s Novel Anti-inflammatory Polysaccharides (NAIP) program into animal models. Further terms were not disclosed....
BioCentury | Nov 3, 1997
Clinical News

Apoptogen preclinical data

Researchers presented data suggesting that a gene therapy system delivering NAIP to brain cells has therapeutic value in animal models of Parkinson's. At the Society for Neuroscience Meeting in New Orleans, the scientists presented data...
BioCentury | Sep 8, 1997
Company News

Apoptogen other research news

Apoptogen and collaborators published data in Nature Medicine showing that increased expression of NAIP prevented death of brain cells in a rat model of stroke. The company plans to explore both gene therapy and small...
BioCentury | Sep 8, 1997
Tools & Techniques

Hoist on its own petard;

Two papers in last week's Cell demonstrate that HIV's mode of entry into T cells can be turned against it. HIV enters T cells by binding to the coreceptors CD4 and CXCR4 . After internalization and...
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