BioCentury | Jun 26, 2020
Distillery Therapeutics

MAP3K7, IL18R1 as targets in obesity-related cerebrovascular dysfunction

...kinase kinase kinase 7 (MAP3K7; TAK1); interleukin-18 receptor 1 (IL18R1; CD218a; IL18RA; IL-18Rα); endothelial cell nitric oxide synthase...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...acid metabolism Thymidylate synthetase (TYMS) 1 Arginine pathway Arginase 1 (ARG1) 8 Nitric oxide synthase 3 Inducible nitric oxide synthase...
BioCentury | May 29, 2018
Preclinical News

IL-1 blockade to treat CAR T side effects

...The Sloan Kettering team investigated proinflammatory cytokine IL-1 due to its role in the inducible nitric oxide synthase...
...forms of juvenile idiopathic arthritis. Elizabeth S. Eaton Kineret, anakinra (Interleukin-1ra (IL-1ra)) San Raffaele Scientific Institute Sloan Kettering Institute Inducible nitric oxide synthase...
BioCentury | May 23, 2018
Distillery Therapeutics

Autoimmune disease

...Next steps could include testing NOS2 inhibitors in additional models of psoriatic arthritis. TARGET/MARKER/PATHWAY: Inducible nitric oxide synthase...
...May 16, 2018 doi:10.1126/sciadv.aas9864 CONTACT: Rikard Holmdahl, Karolinska Institute, Stockholm, Sweden email: rikard.holmdahl@ki.se Claire Quang Karolinska Institute Inducible nitric oxide synthase...
BioCentury | Oct 31, 2017
Distillery Techniques

Biomarkers

...FYN) (rs7757969), membrane associated guanylate kinase WW and PDZ domain containing 2 (MAGI2) (rs323167), neuronal nitric oxide synthase...
...src family tyrosine kinase (FYN) Membrane associated guanylate kinase WW and PDZ domain containing 2 (MAGI2) Neuronal nitric oxide synthase...
BioCentury | Jan 25, 2017
Distillery Therapeutics

Cardiovascular

...aortas compared with vehicle. Next steps include identifying and testing additional NOS2 inhibitors. TARGET/MARKER/PATHWAY: Inducible nitric oxide synthase...
...Spain email: jmredondo@cnic.es Hongjiang Li Autonomous University of Madrid Spanish National Center for Cardiovascular Research Spanish National Research Council Inducible nitric oxide synthase...
BioCentury | Dec 22, 2016
Targets & Mechanisms

Opportunity Knocks

...ANXA1) 6 Cancer Caspase-3 (CASP3; CPP32) 6 Cancer; neurology CD28 6 Cancer; transplant Endothelial cell nitric oxide synthase...
BioCentury | Oct 27, 2016
Targets & Mechanisms

T cell gas, tumor brake

A trio of studies has converged on a common pathway, headed by the PPAR co-activator PGC-1α , to fight cancer and chronic infections by manipulating either T cell immunotherapies or the tumors themselves. While the findings...
BioCentury | Sep 12, 2016
Clinical News

Ronopterin: Phase III started

...Wuerzburg, Germany Product: Ronopterin ( VAS203 ) Business: Inflammation Molecular target: Nitric oxide (NO) synthase Description: Allosteric nitric oxide (NO) synthase...
BioCentury | Jun 23, 2016
Distillery Therapeutics

Therapeutics: Endothelial cell nitric oxide synthase 3 (NOS3; eNOS)

...has the compound in Phase II testing to treat single-ventricle heart disease. TARGET/MARKER/PATHWAY: Endothelial cell nitric oxide synthase...
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