BioCentury | Jun 26, 2020
Distillery Therapeutics

MAP3K7, IL18R1 as targets in obesity-related cerebrovascular dysfunction

...kinase kinase kinase 7 (MAP3K7; TAK1); interleukin-18 receptor 1 (IL18R1; CD218a; IL18RA; IL-18Rα); endothelial cell nitric oxide synthase...
BioCentury | Apr 9, 2020
Product Development

April 8 COVID-19 roundup: National Academy of Sciences says COVID-19 could continue through summer; plus HHS, SAb-CSL, Vanda-UIC, Avacta-Cytiva and more FDA an IND to run the open-label PULSE-CVD19-001 study of INOpulse, a portable inhaled nitric oxide...
BioCentury | Mar 27, 2020
Product Development

COVID-19 roundup: biopharmas scramble to reassess clinical timelines; plus CEPI-Dynavax, and emergency approvals for Vero, Fosun

...through the COVID-19 crisis. The setbacks came as regulators granted emergency access to Vero’s portable nitric oxide...
...March 2. FDA has granted expanded access emergency use to Vero Biotech LLC’s Genosyl inhaled nitric oxide...
...cardiopulmonary symptoms associated with COVID-19. The system is tankless and can be used to delivery nitric oxide...
BioCentury | Mar 13, 2020
Product Development

March 12 Quick Takes: WuXi AppTec’s Wuhan site back online; plus SOX relief, AZ, BMS, Nicox-Ocumesion, Tyligand-Context

...Blanc study. The amendment also expands Ocumension’s development and commercialization rights to NCX 470, a nitric oxide (NO)-donating...
BioCentury | Dec 24, 2019
Company News

Regulatory roundup: BioMarin poised to have first U.S., EU hemophilia gene therapy; plus Allergan, Eisai, FibroGen, ViiV and Vero

...timeline was not disclosed. On Friday, Atlanta-based Vero Biotech LLC said FDA approved Genosyl inhaled nitric oxide...
BioCentury | Aug 15, 2019
Clinical News

At last, a win for terlipressin -- and Mallinckrodt

...for $2.3B" ). While the deal was largely focused on Ikaria's marketed product INOmax inhaled nitric oxide...
BioCentury | Jun 28, 2019
Clinical News

June 28 Clinical Quick Takes: Imfinzi extends survival in Phase III SCLC study; plus LSK, Pfizer, FibroGen, Aclaris and more

...for Revatio in neonatal pulmonary hypertension Pfizer Inc. (NYSE:PFE) said IV Revatio sildenafil plus inhaled nitric oxide...
BioCentury | May 7, 2019
Company News

May 7 Company Quick Takes: Akcea, Bicycle/DDF, Arbutus, Celgene/Sutro, MDGH, Pfizer, Sanofi/Regeneron

...severe asthma with type 2 inflammation characterized by raised blood eosinophils and/or raised fractional exhaled nitric oxide...
BioCentury | Dec 14, 2018
Company News

Shionogi invests in Vast, gains first rights to negotiate license for antimicrobial

...a grant from the Cystic Fibrosis Foundation to support development of BIOC51. BIOC51 is a nitric oxide-releasing...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...acid metabolism Thymidylate synthetase (TYMS) 1 Arginine pathway Arginase 1 (ARG1) 8 Nitric oxide synthase 3 Inducible nitric oxide synthase...
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