00:11 , Jun 13, 2019 |  BC Innovations  |  Translation in Brief

New inflammasome structure from Harvard, SMOC fodder for rational drug design

The ability to rationally design small molecules against a highly sought after inflammasome target -- NLRP3 -- got a boost Wednesday when new structural information was published in Nature by a group from Harvard Medical...
13:50 , Jan 29, 2019 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling; tissue markers Expression levels of a five-gene signature in lung carcinoma in situ lesions could help predict progression to squamous cell lung carcinoma. In biopsy samples from 51 patients with lung carcinoma...
17:38 , Jul 17, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Multiple myeloma (MM) Patient sample and mouse studies suggest inhibiting NEK2 could help treat Velcade bortezomib-resistant MM. In MM patients, high levels of NEK2 in bone marrow plasma cells were associated with poor overall...
19:15 , Mar 7, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture studies suggest inhibiting NEK9 or MAP2K4 could help treat PI3K inhibitor-resistant triple-negative breast cancer (TNBC). In tumor samples from patient-derived xenograft (PDX) mouse models of TNBC, levels of NEK9 and...
01:10 , Dec 7, 2016 |  BC Extra  |  Clinical News

GNS identifies disease drivers from CoMMpass data

GNS Healthcare Inc. (Cambridge, Mass.) said it has identified four genes as "top drivers" of high-risk multiple myeloma. Using its machine learning technology, the company is collaborating with the Multiple Myeloma Research Foundation (MMRF) to...
07:00 , Aug 4, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Variants and SNPs in four genetic loci as risk markers for amyotrophic lateral sclerosis (ALS)

Biomarkers TECHNOLOGY: SNPs Variants and SNPs in four genetic loci could help predict the risk of ALS. Whole-exome sequencing and a rare variant burden screening analysis of 1,022 familial ALS cases and 7,315 unaffected volunteers...
07:00 , Apr 14, 2016 |  BC Innovations  |  Product R&D

AACR by the numbers

See Figure: Top indications See Table: Novel cancer targets at AACR 2016 See Figure: Top institutions and companies See Figure: Top targets Tables Novel cancer targets at AACR 2016 Breast cancer amplified sequence 1 (BCAS1)...
07:00 , Jun 5, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer NDC80 homolog kinetochore complex component (NDC80); NIMA-related kinase 2 (NEK2) SAR studies suggest compounds that block the interaction between NDC80 and NEK2 could help...
07:00 , Apr 23, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Bipolar disorder Inter-alpha trypsin inhibitor heavy chain 1 (ITIH1); Inter-alpha trypsin inhibitor heavy chain 3 (ITIH3); guanine nucleotide binding protein-like-3 (GNL3);...