14:22 , May 14, 2019 |  BC Innovations  |  Distillery Therapeutics

Reducing cellular cholesterol and sphingolipids for lethal jellyfish sting

DISEASE CATEGORY: Other INDICATION: Poisoning Cell culture and mouse studies suggest chelating cellular cholesterol and sphingolipids could help treat poisoning by stings from the Chironex fleckeri jellyfish, which cause cytotoxicity, tissue damage, pain and death....
17:52 , Nov 9, 2018 |  BC Week In Review  |  Clinical News

Mallinckrodt Niemann-Pick disease therapy fails pivotal trial

Mallinckrodt plc (NYSE:MNK) said VTS-270 showed no significant separation from placebo in a Phase IIb/III trial to treat Niemann-Pick disease type C1 (NPC1). Mallinckrodt CSO and EVP Steven Romano disclosed the result on a conference...
21:40 , Nov 6, 2018 |  BC Extra  |  Clinical News

Mallinckrodt Niemann-Pick disease therapy fails pivotal trial

Mallinckrodt plc (NYSE:MNK) said VTS-270 showed no significant separation from placebo in a Phase IIb/III trial to treat Niemann-Pick disease type C1 (NPC1). Mallinckrodt CSO and EVP Steven Romano disclosed the result on a conference...
23:30 , Sep 6, 2018 |  BioCentury  |  Finance

Evox populates its pipeline

As Evox Therapeutics Ltd. continues to refine the platform with which it develops exosome-based therapeutics, the company plans to use its £35.5 million ($45.9 million) series B round to start clinical trials on as many...
14:44 , Jan 9, 2018 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Mouse studies suggest stimulating cholesterol efflux in phagocytes by promoting LXR expression could help treat MS. In a mouse model of lysolecithin-induced MS, cholesterol accumulation in the membranes of lesion-infiltrating phagocytes...
00:38 , Jan 6, 2018 |  BioCentury  |  Finance

Burgeoning bellwethers

  The miserable performance of large cap biotechs last quarter is likely to be a boon for small- and mid-cap players this year, in more ways than one. Buysiders spent most of 2017 focusing to...
20:40 , Jan 5, 2018 |  BC Week In Review  |  Company News

Mallinckrodt acquiring Sucampo

Mallinckrodt plc (NYSE:MNK) said it will acquire Sucampo Pharmaceuticals Inc. (NASDAQ:SCMP) for $18 per share in a deal the companies say values Sucampo at $1.2 billion. The price is a 6% premium to Sucampo's close...
23:32 , Jan 4, 2018 |  BC Extra  |  Preclinical News

Cholesterol efflux in phagocytes may promote remyelination

A report published in Science suggests stimulating cholesterol efflux in phagocytes may promote remyelination in aged individuals, offering a potential regenerative strategy for patients who have had multiple sclerosis or other demyelinating disorders for long...
23:19 , Dec 26, 2017 |  BC Extra  |  Company News

Mallinckrodt acquiring Sucampo

Mallinckrodt plc (NYSE:MNK) said Tuesday it will acquire Sucampo Pharmaceuticals Inc. (NASDAQ:SCMP) for $18 per share in a deal the companies say values Sucampo at $1.2 billion. The price is a 6% premium to Sucampo's...
18:45 , Oct 20, 2017 |  BioCentury  |  Finance

Fast inflections

Longitude Capital joined Cydan Development Inc. ’s syndicate with the expectation that spinouts from the rare disease accelerator can deliver returns within three to five years. The company sources rare disease assets from academia, not-for-profits...