BioCentury | Jun 13, 2018
Distillery Therapeutics

Neurology

...stem (iPS) cells from a patient harboring a GBA mutation, levels of NAD + and nicotinamide nucleotide adenylyltransferase 2 (NMNAT2)...
BioCentury | Sep 6, 2012
Targets & Mechanisms

Passenger mutations take the wheel

Two research groups have independently shown that targeting genes carrying passenger mutations blocked growth of cancer cells and improved survival in mouse models. 1,2 Although precise therapeutic windows for such a strategy remain to be...
BioCentury | Aug 9, 2012
Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Blindness Nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) Studies with human tissues identified multiple NMNAT1 mutations that could help diagnose Leber's congenital amaurosis (LCA). Previous Drosophila...
BioCentury | Feb 11, 2010
Distillery Therapeutics

Indication: Neurology

...NMNAT2 levels could help prevent nerve damage. In murine neurons, small interfering RNA-mediated knockdown of Nmnat2...
...degeneration compared with that seen using control siRNAs. In damaged neurons, compared with controls, increasing Nmnat2...
...levels protected neurites from degeneration. Next steps include conducting studies to evaluate the effects of NMNAT2...
BioCentury | Jun 11, 2009
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Nerve damage Nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) A study in mice and in cell culture suggests that increasing cytoplasmic and axonal...
BioCentury | May 14, 2009
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Nerve damage Nicotinamide nucleotide adenylyltransferase 3 (NMNAT3) A study in mice suggests that increasing mitochondrial expression of NMNAT3 could help delay...
BioCentury | May 7, 2009
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Nicotinamide nucleotide adenylyltransferase 1 (NMNAT1; PNAT1) In vitro studies suggest that increased NMNAT1 enzymatic activity could help prevent axonal degradation...
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