07:00 , Sep 6, 2012 |  BC Innovations  |  Targets & Mechanisms

Passenger mutations take the wheel

Two research groups have independently shown that targeting genes carrying passenger mutations blocked growth of cancer cells and improved survival in mouse models. 1,2 Although precise therapeutic windows for such a strategy remain to be...
07:00 , Aug 9, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Blindness Nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) Studies with human tissues identified multiple NMNAT1 mutations that could help diagnose Leber's congenital amaurosis (LCA). Previous Drosophila...
07:00 , Jun 11, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Nerve damage Nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) A study in mice and in cell culture suggests that increasing cytoplasmic and axonal...
07:00 , May 7, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Nicotinamide nucleotide adenylyltransferase 1 (NMNAT1; PNAT1) In vitro studies suggest that increased NMNAT1 enzymatic activity could help prevent axonal degradation...