BioCentury | May 8, 2014
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...Licensing status Publication and contact information Endocrine/metabolic disease Diabetes; obesity Nicotinamide N-methyltransferase (NNMT) Mouse studies suggest inhibiting NNMT...
...higher levels of Nnmt mRNA in adipose tissue than mice lacking insulin resistance. In mice, Nnmt-targeting...
...by increasing energy expenditure compared with a nontargeting antisense oligonucleotide. Next steps could include testing NNMT...
BioCentury | Mar 21, 2013
Distillery Therapeutics

Indication: Cancer

...and NNMT activity than nonaggressive cancer cell lines. In aggressive cancer cell lines, knockdown of NNMT...
...expression of multiple cancer-associated genes and invasiveness compared with no knockdown. Next steps include developing NNMT...
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