13:30 , Dec 5, 2018 |  BC Innovations  |  Distillery Therapeutics

Hepatic

INDICATION: Non-alcoholic steatohepatitis (NASH) Patient sample and mouse studies suggest inhibiting the Notch pathway components HES1, γ secretase, MAML1 and NCSTN could help treat NASH. In NASH patient liver tissue samples, hepatocyte levels of HES1...
07:00 , Aug 13, 2009 |  BC Innovations  |  Targets & Mechanisms

AD target gets a caution

A Harvard researcher says three new mouse studies reinforce her hypothesis that targeting g-secretase to treat Alzheimer's disease could exacerbate, rather than ameliorate, AD-related neuron loss and brain dysfunction. 1-3 One neurology company targeting g-secretase,...
07:00 , Jun 11, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD) g-Secretase; ^nicastrin (NCSTN) Mouse studies could raise concerns about inhibiting g-secretase to treat AD. Mice engineered for brain-specific,...
07:00 , Jul 31, 2008 |  BC Innovations  |  Targets & Mechanisms

Cleaving Schizophrenia

A study published in the Proceedings of the National Academy of Sciences points to g-secretase, a major Alzheimer's disease target, as a new player in schizophrenia. 1 Although AD work has focused on g-secretase antagonists,...
07:00 , Aug 5, 2002 |  BC Week In Review  |  Company News

Genetics Co. other research news

Researchers published in the Proceedings of the National Academy of Sciences a SNP mapping procedure that relies on resolving polymorphisms by denaturing HPLC without needing to determine the nature of the SNPs. The researchers used...
07:00 , Sep 11, 2000 |  BC Week In Review  |  Company News

University of Toronto other research news

Toronto researchers and colleagues published in Nature the identification of Nicastrin, a transmembrane protein that forms complexes with presenilin proteins ( PS1 and PS2) and is involved with the proteolytic processing of amyloid precursor protein...