...INDICATION: Lung cancer Cell culture studies suggest inhibiting IKK or its scaffold protein NEMO in combination... ...an IKK inhibitor, in preclinical testing to treat pancreatic cancer. TARGET/MARKER/PATHWAY: NF-κ-B essential modifier (NEMO; IKBKG... ...N.C. email: email@example.com
University of North Carolina at Chapel Hill
I-kappa B kinase (IKK)
Mitochondrial complex 1 (MC-1)
NF-kappa-B essential modifier (NEMO) (IKBKG)
...and communications" with FDA, it concluded that the clinical benefit shown in the Phase III NEMO... ...in the indication. In December 2015, Array said binimetinib improved progression-free survival over dacarbazine, meeting NEMO's...