20:34 , Jul 14, 2017 |  BioCentury  |  Strategy

Back to Ipsen’s roots

After spending the last six years plugging revenue holes via licensing and M&A, Ipsen Group is once again on track to meet the 2020 financial targets it set at the beginning of the decade. But...
07:00 , Aug 4, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Neurotensin (NTS)-based PET imaging agents for diagnosing and monitoring treatment responses of neurotensin receptor 1 (NTSR1)-positive tumors

Imaging TECHNOLOGY: PET Neurotensin-based PET imaging agents could help diagnose and monitor treatment-response for NTSR1-positive cancers. Two agents, consisting of a six-amino acid peptide derived from the N-terminus of neurotensin conjugated via linkers to a...
07:00 , May 26, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Neurotensin (NTS); neurotensin receptor 1 (NTSR1); proneurotensin

Endocrine/metabolic disease INDICATION: Obesity Human sample and mouse studies suggest inhibiting NTS- NTSR1 signaling could help treat obesity. In 4,632 obesity patients and healthy volunteers, high fasting plasma levels of the NTS precursor proneurotensin were...
08:00 , Dec 4, 2014 |  BC Innovations  |  Cover Story

GPCRs' grand plans

In a move to expand tenfold the number of known 3D structures of the highly druggable class of GPCRs, Amgen Inc. , Ono Pharmaceutical Co. Ltd. and Sanofi have teamed up with three academic organizations...
07:00 , May 27, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Neurotensin receptor 1 (NTSR1); NTSR2 A study in rats identified a derivative of an analgesic neurotensin hexapeptide that could help treat pain. In four...
07:00 , May 21, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Gastrointestinal disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Gastrointestinal disease Colitis Neurotensin (NTS); NTS receptor 1 (NTSR1) Studies in vitro and in mice suggest that antagonizing NTS or NTSR1 could...