20:41 , Mar 7, 2019 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: February 2019

New Therapeutic Targets and Biomarkers: February 2019 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during February. Therapeutic targets are defined as any protein, gene or other molecule...
13:31 , Feb 13, 2019 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Infectious In vitro and mosquito studies identified a quinazoline-based agonist of A. aegypti NPYLR7 that could help prevent A. aegypti mosquito bites and associated infections. In vitro screening of a compound library in agonistic...
16:19 , May 23, 2018 |  BC Innovations  |  Distillery Techniques

Drug platforms

TECHNOLOGY: Structural analyses Structural analyses of NPY1R bound to tool compound antagonists or its endogenous agonist NPY could guide the design of compounds that antagonize or agonize the receptor for obesity, cancer or bone loss....
19:21 , Jul 13, 2017 |  BC Innovations  |  Translation in Brief

Mind over matter

In the latest link between the GI tract and the CNS, a team from the Max Delbrück Center for Molecular Medicine has identified the synaptic organizers CADM1 and CADM2 as targets in the gut-brain axis...
22:30 , Mar 16, 2017 |  BC Innovations  |  Targets & Mechanisms

Bone appétit!

Last week’s Nature publication of a hormone secreted by bone that suppresses appetite and can curb weight gain not only adds to the emerging picture of bone as a player in the endocrine system but...
08:00 , Feb 13, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Epilepsy Estrogen receptor Mouse studies suggest estradiol or related drugs could be used to treat infantile spasms syndrome (ISS). Estradiol mediates...
08:00 , Jan 9, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine/metabolic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Obesity Neuropeptide Y receptor Y2 (NPY2R); peptide tyrosine-tyrosine (PYY) Mouse studies suggest PYY delivered as an oral spray could help suppress appetite and treat...
07:00 , Oct 17, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Synthesis of therapeutic peptides resistant to degradation by serine proteases A method to render therapeutic peptides resistant to serine proteases could...
07:00 , Jul 19, 2012 |  BC Innovations  |  Targets & Mechanisms

Getting AGRP on obesity

Researchers in New York have identified G protein-coupled receptor 17 as a target on agouti related protein -expressing neurons, which are known to regulate multiple factors related to obesity. 1 The findings open up a...
07:00 , Jul 9, 2012 |  BioCentury  |  Strategy

Belviq breaks through

Arena Pharmaceuticals Inc. and partner Eisai Pharmaceuticals Co. Ltd. will have a fine line to walk as they market Belviq lorcaserin for obesity. They want to improve patient compliance, which historically has not been good...