07:00 , May 14, 2015 |  BC Innovations  |  Tools & Techniques

Editing advantage

A team from the Salk Institute for Biological Studies has developed a technique for editing mitochondrial DNA in one-cell embryos to eliminate mutant mitochondrial genes. While gene editing in embryos has been a flashpoint for...
07:00 , May 14, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Germline genome editing of mitochondrial DNA (mtDNA)

Drug platforms TECHNOLOGY: Gene therapy Mouse studies suggest gene editing of mtDNA could help prevent inherited mitochondrial diseases. A mouse strain with two normal mtDNA haplotypes served as a model of human cells, which can harbor both...
08:00 , Feb 26, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Neuronal pentraxin II (NPTX2; NARP)

Neurology INDICATION: Parkinson's disease (PD) Mouse studies suggest inhibiting NPTX2 could help prevent levodopa-induced dyskinesia in PD patients (PD-LID). In a mouse model of PD-LID, up-regulation of NPTX2 in the striatum correlated with the severity of dyskinesia...