18:25 , Jun 13, 2018 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Cell models A method of directly reprogramming human adult T cells into neurons could be used to generate cell-based models of neurological diseases. The method involves transfecting primary human T cells with a combination...
17:35 , May 25, 2017 |  BC Innovations  |  Emerging Company Profile

Total reprogramming

University of Cambridge spinout Elpis Biomed Ltd. has a platform that rapidly produces stockpiles of pure, mature cell types from human pluripotent stem cells. While the company is first focusing on creating well-defined disease models,...
14:16 , Apr 18, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Cell models A method for differentiating hPSCs into specific cell types by expressing select transcription factors could aid the development of cell-based disease models. The method involved engineering hPSCs via CRISPR-associated protein 9 (Cas9)-guided...
07:00 , Apr 28, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Synthetic biology-based protocol to differentiate human induced pluripotent stem (iPS) cell-derived pancreatic progenitors into mature β-like cells

Drug platforms TECHNOLOGY: Cell therapy A synthetic lineage-control network could program human iPS cell-derived pancreatic progenitor cells into mature β-like cells used to treat diabetes. In human iPS cell-derived pancreatic progenitors, expression of a synthetic...
07:00 , Mar 24, 2016 |  BC Innovations  |  Translation in Brief

Stomaching insulin production

A Harvard University study suggests antral stomach cells share enough features with pancreatic β cells that they can be coached to play the part. The authors think direct reprogramming of this renewable, accessible stomach cell...
08:00 , Feb 25, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: In vivo reprogramming of stomach cells into insulin-secreting pancreatic β-like cells

Drug platforms TECHNOLOGY: Cell therapy Insulin-secreting pancreatic β-like cells derived from renewable stomach cells could help treat diabetes. In mice, gastrointestinal and antral stomach enteroendocrine cells were engineered to express three human genes - neurogenin...
08:00 , Jan 15, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Reprograming fibroblasts into sensory neurons

Disease models TECHNOLOGY: Cell models Direct reprogramming of fibroblasts into sensory neurons could be useful for generating new cellular models to study pain biology and screen for pain-suppressing drugs. Mouse and human embryonic fibroblasts engineered...
08:00 , Jan 8, 2015 |  BC Innovations  |  Tools & Techniques

Pain in the dish

Preclinical models of pain are notorious for their poor ability to translate to humans, and are considered a large part of the reason advances in analgesics have been few and far between. Two independent groups...
07:00 , May 15, 2014 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Direct in vivo reprogramming of pancreatic acinar cells into d-like and a-like pancreatic cells Direct in vivo reprogramming of pancreatic acinar cells into d- and...
07:00 , Jul 18, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms High-yield generation of functional neurons from human induced pluripotent stem (iPS) cells Mouse and cell culture studies suggest the transcription factor...