BioCentury | Jun 20, 2019
Distillery Techniques

Clinically relevant genomic alterations in metastatic breast cancers

...breast cancer (eBC) data identified nine genes -- including p53 (TP53), retinoblastoma 1 (RB1) and neurofibromin...
...May 20, 2019 doi: 10.1038/s41586-019-1056-z CONTACT: Fabrice André, Université Paris Sud, Orsay, France e-mail: fabrice.andre@gustaveroussy.fr Inhua Muijrers-Chen Neurofibromin...
BioCentury | Apr 5, 2019
Targets & Mechanisms

Breaking up Hippo to tame proliferation

...1 MAP2K2 (MEK2) - MAP kinase kinase 2 NF1 - Neurofibromin 1 NF2 (Merlin) - Neurofibromin...
...large tumor suppressor homolog 2 (LATS2) MAP kinase kinase 1 (MAP2K1) (MEK1) MAP kinase kinase 2 (MAP2K2) (MEK2) Neurofibromin...
BioCentury | Jun 21, 2018
Translation in Brief

PHIP the script

...or phosphoinositide 3-kinase catalytic subunit α polypeptide (PI3KCA; p110α) mutations; melanoma lacking BRAF, NRAS, PTEN, neurofibromin...
...Oxford Anaplastic lymphoma kinase (ALK) BRAF Epidermal growth factor receptor (EGFR) (ErbB1) (HER1) K-Ras (KRAS) Neuroblastoma Ras viral (v-Ras) oncogene (NRAS) Neurofibromin...
BioCentury | Jun 12, 2018
Emerging Company Profile

A Cancer Target Revolution

...SHP-2 inhibitors reduced proliferation in lung adenocarcinoma and melanoma cell lines with loss-of-function mutations in neurofibromin...
...and NF1 loss.” bioRxiv (2017) Elizabeth S. Eaton, Staff Writer TNO155 Novartis AG Revolution Medicines Inc. BRAF K-Ras (KRAS) MAP kinase (MAPK) (ERK) Neurofibromin...
BioCentury | Apr 27, 2018
Financial News

Nextech leads Revolution Medicines' $56M series B

...to confer sensitivity to SHP-2 inhibitors in preclinical models, including mutations in the BRAF and neurofibromin...
...AG Revolution Medicines Inc. Schroder Adveq The Column Group Third Rock Ventures BRAF Eukaryotic translation initiation factor 4E binding protein 1 (eIF4EBP1) Neurofibromin...
BioCentury | Apr 27, 2018
Finance

Revolution revamp

...inhibitors reduced cell proliferation in lung adenocarcinoma and melanoma cell lines with loss-of-function mutations in neurofibromin...
...eIF4EBP1). Jaime de León, Staff Writer TNO155 Nextech Invest Novartis AG Revolution Medicines Inc. Third Rock Ventures University of California San Francisco BRAF K-Ras (KRAS) Neurofibromin...
BioCentury | Apr 24, 2018
Financial News

Nextech leads Revolution Medicines' $56M series B

...to confer sensitivity to SHP-2 inhibitors in preclinical models, including mutations in the BRAF and neurofibromin...
...AG Revolution Medicines Inc. Schroder Adveq The Column Group Third Rock Ventures BRAF Eukaryotic translation initiation factor 4E binding protein 1 (eIF4EBP1) Neurofibromin...
BioCentury | Jun 13, 2016
Product Development

Basket cases

...mutation, amplification, translocation or rearrangement Mkt: ALK+ NSCLC Binimetinib (MEK162) (A) MEK Ras, Raf, MEK, neurofibromin...
BioCentury | Oct 5, 2015
Clinical News

Defactinib: Phase II suspended enrollment

...in PFS, the primary endpoint, in either the intent-to-treat (ITT) population or in patients with neurofibromin...
BioCentury | Sep 29, 2015
Clinical News

Verastem halts mesothelioma trial

...pre-planned interim analysis, in both the intent-to-treat population and in patients with tumors low in neurofibromin...
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