BioCentury | Dec 19, 2019
Company News

PharmaMar deal adds late-stage asset to Jazz’s growing cancer pipeline

...in January to develop exosome therapies against five oncogene targets, including historically undruggable intracellular targets NRAS...
...RAF and RAS mutant tumors. Jazz gained $3.88 to $152.27 on Thursday. Targets: NRAS - Neuroblastoma Ras viral oncogene...
BioCentury | Jul 9, 2019
Finance

Revolution raises $100M to build out Ras pipeline, explore SHP-2 combos

...G12C program is in lead optimization. Revolution is also working to inhibit other oncogenic KRAS, NRAS...
...oncogene homolog; KRAS - K-Ras; mTORC1 - Mammalian target of rapamycin complex 1; NRAS - Neuroblastoma Ras viral (v-Ras) oncogene...
...Johnson, Senior Writer AMG 510 MRTX849 RMC-4630 Amgen Inc. Mirati Therapeutics Inc. Revolution Medicines Inc. Sanofi K-Ras (KRAS) Mammalian target of rapamycin complex 1 (mTORC1) Neuroblastoma Ras viral (v-Ras) oncogene (NRAS) Src...
BioCentury | Jun 28, 2019
Product Development

How Array stayed alive long enough to grow up

...$132.3 million at $6.25 per share 3/19/17 - Withdraws NDA for Mektovi monotherapy to treat neuroblastoma Ras viral (v-Ras) oncogene (NRAS)-mutant...
BioCentury | Jun 3, 2019
Clinical News

June 3 ASCO Quick Takes: ORR of 32% for Celgene's iberdomide in MM; plus Five Prime, Iovance and more

...Phase I trial that enrolled 54 patients with advanced or metastatic cancer. One patient with NRAS-mutant...
...Cyclin dependent kinase 6; FGFR1 (CD331) - Fibroblast growth factor receptor 1; NRAS - Neuroblastoma Ras viral (v-Ras) oncogene...
BioCentury | Apr 5, 2019
Targets & Mechanisms

Breaking up Hippo to tame proliferation

...models of pediatric neuroblastoma. Data from the collaboration were reported at AACR. In NF1- or NRAS-mutated...
...MAP kinase kinase 2 NF1 - Neurofibromin 1 NF2 (Merlin) - Neurofibromin 2 NRAS - Neuroblastoma Ras viral (v-Ras) oncogene...
BioCentury | Feb 11, 2019
Distillery Therapeutics

Cancer

...cell culture and mouse studies identified a quinazolinamine-based STK19 inhibitor that could help treat NRAS-mutant...
...quinazolinamine-based compound that inhibited STK19 with an IC 50 of 24 nM. In two human NRAS-mutant...
...lines, the compound decreased growth compared with no treatment. In a xenograft mouse model of NRAS-mutant...
BioCentury | Jan 4, 2019
Company News

Codiak, Jazz to develop exosomes against tricky oncogenes

...to be developed using Codiak's engEx precision engineering platform. The deal includes therapies against neuroblastoma Ras viral oncogene (NRAS...
...Inc., Cambridge, Mass. Jazz Pharmaceuticals plc (NASDAQ:JAZZ), Dublin, Ireland Business: Cancer Jennie Walters Cydan Development Inc. Jazz Pharmaceuticals plc Neuroblastoma Ras viral (v-Ras) oncogene (NRAS) Signal...
BioCentury | Jan 3, 2019
Company News

Codiak, Jazz to develop exosomes against tricky oncogenes

...tumors to be developed using Codiak's engEx precision engineering platform. The deal includes therapies against NRAS...
...$0.88 to $126.01 on Thursday; the companies announced the deal after market close. NRAS - Neuroblastoma Ras viral oncogene...
...Neuroblastoma Ras viral oncogene; STAT3 - Signal transducer and activator of transcription 3 Jennie Walters Codiak BioSciences Inc. Jazz Pharmaceuticals plc Neuroblastoma Ras viral (v-Ras) oncogene (NRAS) Signal...
BioCentury | Nov 6, 2018
Distillery Techniques

Assays and screens; biomarkers

...harboring runt-related transcription factor 1 (RUNX1) mutations; resistance to Zelboraf vemurafenib in tumors harboring neuroblastoma Ras viral oncogene (NRAS...
BioCentury | Sep 26, 2018
Distillery Techniques

Assays and screens; other

...receiving anti-EGFR therapy to measure the frequency of common mutations in BRAF, K-Ras (KRAS), neuroblastoma Ras viral oncogene (NRAS...
...Quang Erbitux, cetuximab (IMC-C225) Vectibix, panitumumab (ABX-EGF) The Institute of Cancer Research BRAF Epidermal growth factor receptor (EGFR) (ErbB1) (HER1) K-Ras (KRAS) Neuroblastoma Ras viral (v-Ras) oncogene (NRAS) Protein...
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