BioCentury | Sep 14, 2017
Emerging Company Profile

RNA gets CRISPR

Two of the outstanding hurdles for CRISPR-based gene editing are the safety concerns of permanently changing the cell’s DNA and the efficacy limitations of relying on natural DNA repair mechanisms to fix the cuts. Locana...
BioCentury | Oct 13, 2016
Product R&D

Elastic bones

...is developing recombinant NELL1 for bone repair. In June, Bone Biologics licensed rights to use NELL1...
...Biologics is testing the best way to combine NELL1 protein and demineralized bone matrix. "The NELL1...
...and Compounds BMP2 - bone morphogenetic protein 2 COL1 - collagen type I NELL1 - NEL-like protein 1...
BioCentury | Jun 27, 2016
Company News

UCLA, Bone Biologics deal

...rights to use NEL-like protein 1 (NELL1) to treat osteoporosis. Bone Biologics is funding development of a NELL1-based...
BioCentury | Jul 23, 2015
Distillery Therapeutics

Therapeutics: NEL-like protein 1 (NELL1)

...Musculoskeletal disease INDICATION: Osteoporosis Cell culture, mouse and sheep studies suggest NELL1 could help treat osteoporosis...
...human bone marrow stem cells from osteoporosis patients and healthy controls, an adenoviral vector encoding NELL1...
...a NELL1 protein in preclinical development for myocardial infarction (MI) and tissue damage. TARGET/MARKER/PATHWAY: NEL-like protein 1 (NELL1...
BioCentury | Apr 5, 2010
Clinical News

NellOne preclinical data

...In mouse cardiomyocytes in vitro, the Nell1 protein provided significant protection and prevented cell death upon...
...inhibitor L-monomethylarginine. NellOne has an exclusive, worldwide license to patents covering the gene encoding NEL-like protein 1 (NELL1...
...damaged heart tissue based on the Nell1 gene. NellOne Therapeutics Inc. , Knoxville, Tenn. Product: Nell1...
BioCentury | Apr 5, 2010
Clinical News

NellOne preclinical data

...In a diabetic mouse model of skeletal muscle wound, Nell1 protein significantly increased new blood vessel...
...control mice. NellOne has an exclusive, worldwide license to patents covering the gene encoding NEL-like protein 1 (NELL1...
...damaged heart tissue based on the Nell1 gene. NellOne Therapeutics Inc. , Knoxville, Tenn. Product: Nell1...
BioCentury | Feb 8, 2010
Company News

NellOne, U.S. Department of Energy deal

...NellOne received an exclusive, worldwide license to patents covering the gene encoding NEL-like protein 1 (NELL1) , a...
...use research from DOE to develop protein therapeutics to repair damaged heart tissue based on Nell1...
BioCentury | Mar 2, 2009
Clinical News

Bone Biologics preclinical data

...3 months without cystic lesions and ectopic bone growth. UCB-1 is a recombinant NEL-like protein (NELL1...
BioCentury | Jun 9, 2008
Company News

Battelle Ventures L.P., U.S. Department of Energy cardiovascular news

...therapeutics will be based on the discovery by the DoE's Oakridge National Laboratory that NEL-like protein 1 (NELL1...
BioCentury | Jun 5, 2008
Company News

Battelle Ventures spins out NellOne

...attack. The newco's products will be based on the Oak Ridge discovery that the NEL-like protein 1 (NELL1...
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