BioCentury | Feb 8, 2018
Translation in Brief

Proteomic pathfinding

Biognosys is using a method developed by ETHZ researchers for the unbiased detection of molecular targets based on protein-metabolite interactions to study inter- and intra-patient variances in the proteome. The protein services CRO will also...
BioCentury | May 6, 2017
Strategy

mDx blueprint

...into the bowel. Specifically, Cologuard detects hypermethylation in the promoter regions of the NDRG family member 4 (NDRG4; SMAP-8...
BioCentury | Jun 25, 2009
Distillery Therapeutics

Indication: Cancer

...colorectal cancer. Methylation of the promoter region of NDRG4 was higher and expression of the NDRG4...
...lines decreased cell proliferation and invasiveness, confirming NDRG4 as a tumor suppressor. A screen of NDRG4...
...with colorectal cancer with >50% sensitivity and >90% specificity. Ongoing work is seeking to validate NDRG4...
BioCentury | Apr 21, 2008
Clinical News

MethylGene, Pharmion, Taiho preclinical data

In vitro, MGC0103 upregulated the N-myc downregulated gene 1 (NDRG1), which led to the differentiation of prostate cancer cells and decreased metastasis. MethylGene said NDRG1 is a prostate cancer metastasis suppressor gene. Pharmion has rights...
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