BioCentury | Aug 14, 2020
Finance

Aug. 13 Quick Takes: Qiagen shareholders opt for independence; plus IPO terms from Inhibrx, Harmony and more from Biohaven-Royalty, Scioto, Bodyport, immunoSCAPE

Qiagen to remain independent Qiagen N.V. (NYSE:QGEN; Xetra:QIA) said it terminated its agreement to be acquired by Thermo Fisher Scientific Inc. (NYSE:TMO) after only 47% of shares were tendered by Qiagen shareholders, well below the...
BioCentury | Jul 18, 2019
Distillery Therapeutics

Small molecule NPR1 inhibitors for itch

DISEASE CATEGORY: Dermatology INDICATION: Itch NIH researchers identified 15 small molecule human NPR1 inhibitors through cell-based screening that could treat itch. The compounds inhibited NRP1, a receptor for a neuropeptide that promotes itch, with IC...
BioCentury | May 8, 2019
Company News

Why dwarfism start-up Therachon picked Pfizer takeout over IPO

...the most advanced candidate to treat the disorder. Vosoritide, a CNP analog which binds to NPR2...
...FGFR3 (CD333) - Fibroblast growth factor receptor 3; GLP-2 - Glucagon-like peptide-2; NPR2 (NPRB) - Natriuretic peptide receptor B Paul...
BioCentury | Mar 21, 2018
Company News

Weather delay for achondroplasia meeting

...analog resistant to neutral endopeptidase (neprilysin; MME; NEP; CD10) digestion, which binds to natriuretic peptide receptor B (NPR2; NPRB...
BioCentury | Apr 6, 2017
Targets & Mechanisms

Competing for growth

...a stable analog of the peptide agonist CNP that acts via the cell surface receptor NPR2...
...CD333) - fibroblast growth factor receptor 3; MAPK (ERK) - MAP kinase; NPR2 (NPRB) - natriuretic peptide receptor B...
...Fibroblast growth factor FGFR3 (CD333) - Fibroblast growth factor receptor 3 NPR2 (NPRB) - Natriuretic peptide receptor B...
BioCentury | Dec 14, 2016
Clinical News

Vosoritide: Ph III started

...Japan Product: Vosoritide (BMN 111) (formerly BMN-111) Business: Musculoskeletal Molecular target: Natriuretic peptide receptor B ( NPR2 ; NPRB...
...resistant to neutral endopeptidase ( neprilysin ; MME ; NEP; CD10) digestion, which binds to NPR2...
...year; proportionality and functionality Status: Phase III started Milestone: NA Julian Zhu BMN 111 Vosoritide BioMarin Pharmaceutical Inc. Natriuretic peptide receptor B (NPR2) (NPRB...
BioCentury | Apr 13, 2015
Clinical News

Cenderitide: Completed Phase II enrollment

...NPRA); Natriuretic peptide receptor B (NPR2) (NPRB) Description: Selective natriuretic peptide receptor A (NPR1; NPRA) and natriuretic peptide receptor B (NPR2; NPRB...
BioCentury | Mar 9, 2015
Clinical News

Cenderitide: Phase II started

...Natriuretic peptide receptor B (NPR2) (NPRB) Description: Selective natriuretic peptide receptor A (NPR1; NPRA) and natriuretic peptide receptor B (NPR2; NPRB...
BioCentury | Nov 24, 2014
Company News

Medtronic, Capricor Therapeutics deal

...of the patents. Cenderitide is a selective natriuretic peptide receptor A ( NPRA ) and NPRB...
BioCentury | Jul 15, 2013
Company News

Capricor, Nile Therapeutics deal

...a selective natriuretic peptide receptor A ( NPR1 ; NPR1) and natriuretic peptide receptor B ( NPR2 ; NPRB...
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