BC Innovations | May 24, 2018
Translation in Brief

Click chemistry HATRIC

Researchers at ETH Zurich have developed a click chemistry-based screening method that can identify all cell surface proteins that bind a ligand. The hope is that surface proteins exclusively present on select cell types will...
BC Innovations | Apr 11, 2017
Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell culture and mouse studies suggest Na+/K+ ATPase pump inhibitors could help treat glioma. In seven human glioma cell lines, the Na+/K+ ATPase pump inhibitor oleandrin decreased cell viability and migration compared...
BC Week In Review | Aug 22, 2016
Company News

Lee’s Pharmaceutical Holdings Ltd., ScinoPharm Taiwan deal

Lee’s Pharmaceutical’s CVie Therapeutics Ltd. subsidiary and ScinoPharm partnered to discover and develop “orally available” analogs of CVie’s istaroxime . Istaroxime, a luso-inotropic agent that inhibits Na+/K+ ATPase pump and activates ATPase Ca++ transporting cardiac muscle...
BC Innovations | Nov 5, 2015
Distillery Therapeutics

Therapeutics: Na+/K+ ATPase pump; Src

Endocrine/metabolic disease INDICATION: Obesity In vitro and mouse studies suggest a peptide inhibitor of Src could help treat obesity. Previous studies identified a 20-amino acid peptide derived from the ATP binding domain of the Na+/K+...
BC Week In Review | Jun 29, 2015
Clinical News

RX108: Phase I started

Suzhou NeuPharma began an open-label, Australian Phase I trial of Rx10 8. Suzhou NeuPharma Co. Ltd. , Suzhou, China   Product: Rx10 8   Business: Cancer   Molecular target: Na+/K+ ATPase pump   Description: Small molecule...
BC Innovations | Aug 18, 2011
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Na/K ATPase pump; src Mouse and cell culture studies suggest inhibiting src signaling with an Na/K ATPase-derived peptide could...
BC Innovations | Dec 2, 2010
Distillery Therapeutics

Indication: Various

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Autoimmune; inflammation Interferon-b (IFNB; IFN-b); Na+/K+ ATPase pump In vitro studies suggest that cardiac glycosides could help to treat autoimmune and...
BC Innovations | Dec 2, 2010
Targets & Mechanisms

Cardiac glycosides: a leap to lupus

A team from Harvard University and Columbia University College of Physicians and Surgeons has found that cardiac glycosides, a diverse family of sodium pump blockers that are used to treat heart failure and atrial arrhythmia,...
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