BioCentury | Nov 25, 2020
Product Development

Data Byte: a snapshot of the clinical cutaneous T cell lymphoma pipeline

...Interleukin-9IL-12 – Interleukin-12KIR3DL2 (CD158K) – Killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 2 MicroRNA-155 (miR-155)PD1...
BioCentury | Oct 24, 2020
Translation in Brief

UNC Chapel Hill Angelman gene therapy rescues motor function; plus data backing planned Pacylex, Kronos clinical trials and more

...company, which published the data in the European Heart Journal, is evaluating the antisense oligonucleotide against miR-132...
...blastocyst-stage embryos developed from the two-cell embryo stage.TARGETSATXN3 – Ataxin 3 CDK9 – Cyclin dependent kinase 9 miR-132...
BioCentury | Sep 5, 2020
Translation in Brief

Matt Disney’s microRNA-targeting angiogenesis compound; Arrakis’ platform to find compounds’ RNA targets; dual target CAR Ts for HIV and more

...a compound that targets a  precursor of miR-377...
...Chemistry article, the researchers had identified the miR-377...
...HUVECs) that it reduced levels of mature miR-377...
BioCentury | May 28, 2020
Distillery Therapeutics

microRNA cluster identified as targets for ischemic stroke

...DISEASE CATEGORY: Neurology INDICATION: Stroke Targeting the miR-15a/miR-16-1 cluster to enhance blood-brain barrier function could treat...
...cell surface protein involved in maintaining paracellular barriers and regulating permeability. TARGET/MARKER/PATHWAY: MicroRNA-15a (miR-15a); microRNA-16-1 (miR-16-1...
...Yin, University of Pittsburgh School of Medicine, Pittsburgh, Pa. email: yink2@upmc.edu Claire Quang University of Pittsburgh MicroRNA-15a (miR-15a) MicroRNA-16-1 (miR-16-1) Claudin...
BioCentury | May 20, 2020
Product Development

BARDA takes steps to secure supply chain as more companies look to scale up manufacturing

...reaches the market. Last week, France cleared the start Abivax’s randomized, double-blind, placebo-controlled Phase IIb/III miR-AGE...
...for ulcerative colitis. The small molecule blocks viral replication by binding CBC, and also upregulates miR-124...
...an allogeneic cell therapy derived from human bone marrow. Targets CBC - Cap binding complex miR-124...
BioCentury | May 15, 2020
Product Development

Repurposed autoimmune therapies head for controlled COVID-19 studies in Europe

...which was initially developed for HIV, blocks viral replication by binding CBC. ABX464 also upregulates miR-124...
...“Fine-Tuning Therapeutic Protein Expression” ). Targets CBC - Cap binding complex DHODH - Dihydroorotate dehydrogenase miR-124...
BioCentury | Feb 28, 2020
Distillery Therapeutics

An antisense oligo inhibitor of miR-132 for heart failure

...DISEASE CATEGORY: Cardiovascular INDICATION: Heart failure The miR-132 inhibitor CDR132L could treat heart failure. In pigs...
...NASDAQ:RGLS) has the miR-132 inhibitor anti-miR-132 in preclinical testing for non-alcoholic steatohepatitis (NASH). TARGET/MARKER/PATHWAY: MicroRNA-132 (miR-132...
BioCentury | Feb 1, 2020
Preclinical News

Cardior eyes heart failure cure with miRNA inhibitor

...cardiovascular diseases. Its lead candidate is CDR132L, a locked nucleic acid (LNA) antisense oligonucleotide against miR-132...
...other company, Regulus Therapeutics Inc. (NASDAQ:RGLS), is developing a miR-132 inhibitor. Its antisense oligonucleotide against miR-132...
...inhibitor. Its antisense oligonucleotide against miR-132 is in preclinical testing for non-alcoholic steatohepatitis (NASH). Targets: miR-132...
BioCentury | Jan 21, 2020
Tools & Techniques

Disney lab uncovers another RNA-binding small molecule for triple-negative breast cancer

...and colleagues showed that a small molecule construct designed to degrade the precursor of oncogenic miR-21...
...EGFR2; ErbB2; neu) - Epidermal growth factor receptor 2 miR-21 - MicroRNA-21 miR-210 - MicroRNA-210 miR-515...
...MicroRNA-21 miR-210 - MicroRNA-210 miR-515 - MicroRNA-515 Lauren Martz, Senior Editor Scripps Research Institute Expansion Therapeutics Inc. MicroRNA-21 (miR-21) Triple-negative...
BioCentury | Dec 17, 2019

miR-130b mimics to treat sepsis

...DISEASE CATEGORY: Infectious disease INDICATION: Sepsis The microRNA miR-130b could treat sepsis by inhibiting CIRP, a...
...could treat sepsis by inhibiting CIRP, a damage-associated molecular pattern (DAMP) protein. Serum levels of miR-130b...
...In two mouse models, one with CIRP-induced systemic inflammation and one with polymicrobial sepsis, a miR-130b...
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