BC Innovations | Apr 10, 2019
Distillery Therapeutics

Inhibiting a MYLK splice variant for IBD and colitis

DISEASE CATEGORY: Autoimmune; gastrointestinal INDICATION: Inflammatory bowel disease (IBD); colitis Cell culture and mouse studies identified an inhibitor of an MYLK isoform that could help treat IBD and colitis. In silico screening of a compound...
BC Week In Review | Nov 25, 2013
Clinical News

Neuroptis preclinical data

In rats, pretreatment with an eye drop formulation of ML7 significantly reduced ophthalmic inflammation induced by benzalkonium chloride compared to vehicle-treated controls (p<0.05). Data were published in Investigative Ophthalmology and Visual Science. "In the next...
BC Innovations | Nov 11, 2010
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Herpes simplex virus (HSV) Myosin heavy chain 9 (MYH9); myosin light chain kinase (MYLK; MLCK) Cell culture and mouse studies suggest that inhibiting MYH9...
BioCentury | Apr 23, 2007
Tools & Techniques

Ranking the kinase kingdom

After four years of work, researchers at the Wellcome Trust Sanger Institute and colleagues have elucidated the prevalence and signature of somatic mutations in human protein kinases. The findings, recently reported in Nature , have provided...
BC Week In Review | May 5, 2003
Company News

Northwestern University other research news

Researchers published in the Proceedings of the National Academy of Sciences that MLCK210 knockout mice were less susceptible to lipopolysaccharide (LPS)-induced ALI compared to control (p<0.001), and showed enhanced survival during subsequent mechanical ventilation (p=0.001)....
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