BioCentury | Jul 30, 2015
Targets & Mechanisms

Muscling in on atherosclerosis

...of smooth muscle cells over time in a mouse model of atherosclerosis, the researchers used MYH11...
...but was not restricted to cells expressing smooth muscle cell markers such as ACTA2 or MYH11...
...EZF ) - Kruppel-like factor 4 LGALS3 - Galectin-3 MYH11 ( SMMHC ) - Myosin heavy chain 11 smooth muscle...
BioCentury | Mar 12, 2015
Distillery Therapeutics

Therapeutics: Core-binding factor β subunit (CBFB; CBF-β); myosin heavy chain 11 smooth muscle (MYH11; SMMHC); runt-related transcription factor 1 (RUNX1)

...could help treat the inv(16) subtype of AML. The subtype is driven by an oncogenic CBFB-SMMHC...
...Next steps include optimizing the compound. TARGET/MARKER/PATHWAY: Core-binding factor β subunit (CBFB; CBF-β); myosin heavy chain 11 smooth muscle (MYH11; SMMHC...
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