02:12 , Dec 1, 2018 |  BioCentury  |  Politics, Policy & Law

China’s germline growing pain

How Chinese regulatory authorities respond over the long term to the CRISPR baby furor could influence its industry’s success on the global stage, as domestic and international stakeholders seek reassurance that the authorities are on...
01:45 , Nov 17, 2018 |  BioCentury  |  Product Development

MyoKardia’s myosin mechanism deconvolution

With preclinical proof of concept that its lead candidate mavacamten acts via two distinct mechanisms to treat cardiomyopathy, MyoKardia Inc. is ready to accelerate a pipeline of preclinical programs that exploit the mechanisms separately for...
23:35 , Aug 22, 2018 |  BC Innovations  |  Translation in Brief

Confirming CRISPR

Two critiques of a 2017 human embryo gene editing study, including one suggesting large deletions at the target site misled researchers into thinking CRISPR-Cas9 corrected a genetic mutation, raise questions about what assays and screening...
13:36 , Sep 14, 2017 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: August 2017

New Therapeutic Targets and Biomarkers: August 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during August 2017. Therapeutic targets are defined as any protein, gene or other...
18:32 , Aug 9, 2017 |  BC Innovations  |  Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy CRISPR- Cas9 gene editing could be used to correct disease-causing mutations in human embryos. Human embryos were created by combining healthy donor oocytes from 12 women and sperm from a patient with...
23:24 , Aug 3, 2017 |  BC Innovations  |  Tools & Techniques

The other side of the Rubicon

In the end, it might be the efficacy that guides the ethics. By showing that editing of human embryos using CRISPR can be performed efficiently and without leading to the much-feared slew of off-target cuts,...
17:19 , Aug 2, 2017 |  BC Extra  |  Preclinical News

U.S. researchers buck embryo editing guidelines

In direct contravention of the position against germline gene editing taken by NIH, a team led by scientists from Oregon Health & Science University published a study in Nature on Wednesday detailing CRISPR-Cas9-mediated gene correction...