BioCentury | Nov 10, 2020

Label expansions coming at a rapid clip for Foundation’s blood-based companion cancer diagnostic

In the past three weeks, FDA has added four companion diagnostic indications to the label of Foundation Medicine’s liquid biopsy test, growing the number of genetic biomarkers indicated for matching patients to targeted therapies. The...
BioCentury | Sep 24, 2020

Sept. 23 Quick Takes: Zai raises $776M, Silverback $85M; plus Novartis, PureTech, UCB and more

Zai prices Hong Kong offering, becomes dual-listedCross-border in-licensing company Zai Lab Ltd. (NASDAQ:ZLAB; HKEX:9688) raised HK$5.9 billion ($776.1 million) via an offering that will land it on the Hong Kong stock exchange. The deal’s combined...
BioCentury | May 26, 2020
Distillery Therapeutics

Targeting the super elongation complex for diffuse midline glioma

DISEASE CATEGORY: Cancer INDICATION: Brain cancer Inhibiting AFF4 and CDK9, components of the transcription-regulating super elongation complex, could treat diffuse midline glioma. In human diffuse midline glioma cell lines, shRNAs targeting AFF4 or CDK9 or...
BioCentury | May 14, 2020
Emerging Company Profile

Kriya emerges with $80.5M A round, three gene therapies for diabetes and obesity

A team of gene therapy veterans from the likes of Sangamo, Spark and AveXis have debuted Kriya with an untranched $80.5 million series A round to bring gene therapies to patients with prevalent and severe...
BioCentury | Dec 9, 2019
Company News

U.S. government contracting with Sanofi to double recombinant influenza vaccine capacity

The U.S. government has entered into a six-year, $226 million contract with the Sanofi Pasteur division of Sanofi to double the company’s recombinant protein-based influenza vaccine manufacturing capacity in the United States. The contract will...
BioCentury | Nov 2, 2019
Company News

Management tracks: Genmab, Kintai, Aerie, Oasmia, Sangamo, Ovid, Checkmate, Third Pole, Actimed, IMV, Entasis, Rafael, Evaxion and Arvelle

David Eatwell will retire as CFO and EVP of Genmab A/S (CSE:GMAB; NASDAQ:GMAB) on Feb. 29. The cancer antibody therapy company will promote Anthony Pagano, SVP finance and corporate development, to CFO and EVP, effective...
BioCentury | Aug 26, 2019
Product Development

Vax to the future: How Anthony Fauci is thinking about next-gen vaccines and other NIAID priorities

From his vantage point overseeing NIH’s infectious disease agenda, Anthony Fauci has identified vaccine development as an area poised to make big leaps. He says the institute’s prioritization of platform technologies holds more promise than...
BioCentury | Jun 20, 2019
Company News

Beyond Keytruda: Merck details plans for future growth

Merck is looking beyond its blockbuster cancer drug Keytruda pembrolizumab to late-stage programs in infectious disease, vaccines and chronic indications to help the pharma weather any revenue shortcomings when its diabetes drug Januvia sitagliptin comes...
BioCentury | Jun 4, 2019
Distillery Therapeutics

PDE-1 inhibition could treat heart failure

DISEASE CATEGORY: Cardiovascular INDICATION: Heart failure Mouse studies suggest PDE-1 inhibitors could help treat a subtype of heart failure. In a mouse model of cardiac proteinopathy-induced heart failure with preserved ejection fraction, a tool compound...
BioCentury | May 8, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: April 2019

New Therapeutic Targets and Biomarkers: April 2019 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during April. Therapeutic targets are defined as any protein, gene or other molecule...
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