BioCentury | Dec 2, 2020
Distillery Therapeutics

Oligodendrocyte-derived extracellular vesicles for multiple sclerosis

...of mature oligodendrocytes differentiated from mouse oligodendrocyte progenitor cells. In mouse models of MS mediated by anti-MOG...
...extracellular vesicles induced expression of PD-1 in spleen and CNS, a marker of apoptosis in anti-MOG...
...cells, and decreased markers of neuropathology, demyelination and axonal damage. The vessicles reduced clinical disease scores and increased survival. TARGET/MARKER/PATHWAY: Myelin oligodendrocyte glycoprotein (MOG)...
BioCentury | Oct 14, 2019
Financial News

Mogrify raises $16M, outlines plans to advance cell therapy platform

...so you can scale it and manufacture it,” Disley said. Mogrify’s lead programs, MOG-001 and MOG-002...
BioCentury | Sep 19, 2019
Product Development

Anokion puts liver to the test

...experimental autoimmune encephalitis (EAE) mouse model of multiple sclerosis (MS). LT-MOG comprises an MS autoantigen, MOG...
...in immune tolerance induction. In the mouse model of MS, LT-MOG decreased the percent of MOG-reactive...
...LT-MOG also completely prevented disease development when given prior to the appearance of symptoms, whereas MOG...
BioCentury | Mar 26, 2019
Distillery Therapeutics

The short-chain fatty acid pentanoate for MS

...RORC; RORγ). In mouse models of MS induced by exposure to an antigenic epitope in myelin oligodendrocyte glycoprotein (MOG)...
...and CD4 + T cells in the CNS compared with no treatment, and in the MOG...
...pentanoate decreased the number of CD8 + T cells in the CNS. Also in the MOG...
BioCentury | Jan 25, 2019
Product R&D

Rubius turns immunotherapy red

...a presentation at the 2018 Jefferies London Healthcare Conference, the company showed RBCs bearing a MOG...
...Human leukocyte antigen IL-12 - Interleukin-12 IL-15 - Interleukin-15 IL-15RA - Interleukin-15 receptor alpha chain MOG...
BioCentury | Dec 11, 2018
Translation in Brief

Diseased oligodendrocytes

...OPCs from the model increased the survival and proliferation of mouse T cells specific for myelin oligodendrocyte glycoprotein (MOG)...
...of MS. Chris Lieu, Staff Writer Karolinska Institute Major histocompatibility complex class I (MHCI) Major histocompatibility complex class II (MHCII) Myelin oligodendrocyte glycoprotein (MOG) Multiple...
BioCentury | Jul 25, 2017
Distillery Techniques

Drug platforms

...antibody targeted for clearance. In mice injected with radiolabeled antibodies against myelin oligodendrocyte glycoprotein ( MOG...
...or epidermal growth factor receptor 2 ( HER2 ; EGFR2 ; ErbB2 ; neu), engineered Fc-MOG...
...Tuzman Texas A&M University Epidermal growth factor (EGF) receptor 2 (HER2) (ErbB2) (neu) Fc gamma receptor (FCGR) Immunoglobulin G1 (IgG1) Myelin oligodendrocyte glycoprotein (MOG) Neonatal...
BioCentury | May 31, 2017
Distillery Therapeutics

Autoimmune disease

...EAE) mouse model of MS, overexpression of ERDR1 in T cells decreased the number of MOG...
...promote the expression of ERDR1 in models of MS. TARGET/MARKER/PATHWAY: Erythroid differentiation regulator 1 (ERDR1); myelin oligodendrocyte glycoprotein (MOG)...
...Round, University of Utah School of Medicine, Salt Lake City, Utah email: june.round@path.utah.edu Hongjiang Li University of Utah Myelin oligodendrocyte glycoprotein (MOG)...
BioCentury | Apr 11, 2017
Distillery Therapeutics

Autoimmune disease; endocrine / metabolic

...chemical reaction. In a mouse model of MS, infusion of mouse RBCs decorated with a MOG...
...RBCs. Next steps could include testing autoantigen-decorated RBCs in models of other autoimmune diseases. TARGET/MARKER/PATHWAY: Myelin oligodendrocyte glycoprotein (MOG)...
...lodish@wi.mit.edu CONTACT: Hidde L. Ploegh, same affiliation as above email: hidde.ploegh@childrens.harvard.edu Karen Tkach Whitehead Institute for Biomedical Research Myelin oligodendrocyte glycoprotein (MOG) Multiple...
BioCentury | Mar 31, 2016
Distillery Therapeutics

Therapeutics: Sialic acid; myelin oligodendrocyte glycoprotein (MOG)

...In the mouse experimental autoimmune encephalomyelitis (EAE) model of MS, DCs preincubated with sialic acid- MOG...
...splenocyte production of effector T cells and inflammatory cytokines compared with DCs preincubated with free MOG...
...could include testing sialic acid-antigen conjugates in additional models of autoimmune disease. TARGET/MARKER/PATHWAY: Sialic acid; myelin oligodendrocyte glycoprotein (MOG)...
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