BioCentury | Dec 19, 2018
Distillery Therapeutics

Neurology

...in healthy infants. In a mouse model of necrotizing enterocolitis, intestinal epithelium-specific HMGB1 knockout increased myelin basic protein (MBP)...
BioCentury | Aug 17, 2018
Targets & Mechanisms

Unsaturated remyelination

...ability to inhibit CYP51 correlated directly with their ability to induce differentiation of OPCs into MBP-positive...
BioCentury | Dec 1, 2016
Targets & Mechanisms

Not a peripheral story

...one such peptide-based therapy, ATX-MS-1467 , a combination of four synthetic peptides derived from human MBP...
...amyloid polypeptide IFNγ - Interferon γ IL-4 (BSF1) - Interleukin-4 IL-5 - Interleukin-5 MBP - myelin basic protein...
BioCentury | Oct 24, 2016
Company News

Apitope, Merck KGaA deal

...Apitope, terminating the partners’ 2009 deal. The vaccine containing four synthetic peptides derived from human myelin basic protein...
BioCentury | Oct 17, 2016
Company News

Merck KGaA returns rights to Apitope's vaccine

...to treat relapsing MS. It is a vaccine containing four synthetic peptides derived from human myelin basic protein...
BioCentury | May 9, 2016
Emerging Company Profile

Deliver to the liver

...Center Hamburg-Eppendorf , where liver immunology researcher Johannes Herkel and colleagues found atopic expression of myelin basic protein (MBP)...
BioCentury | Sep 28, 2015
Company News

UCSD, PsychoGenics deal

...system atrophy (MSA). The Line 1 model overexpresses human wild-type SNCA under control of the myelin basic protein (MBP)...
BioCentury | Sep 14, 2015
Clinical News

ATX-MS-1467: Completed Phase IIa enrollment

...Major histocompatibility complex class I (MHC) Description: Vaccine containing 4 synthetic peptides derived from human myelin basic protein...
BioCentury | Jul 16, 2015
Finance

Foundation in disrepair

...compounds that can increase differentiation of oligodendrocytes precursor cells (OPCs) into oligodendrocytes 4 days 30 Myelin basic protein (MBP)...
...axons of co-cultured CNS neurons; assess effects on differentiation 2 weeks 40 Morphological change (myelination); MBP...
BioCentury | Jan 19, 2015
Emerging Company Profile

Unlocking PADs

...increased PAD activity and citrullinated proteins including myelin basic protein (MBP) are found in patients' brains. Citrullination of MBP...
...demyelination. A PAD inhibitor could slow or prevent demyelination and reduce the production of citrullinated MBP...
Items per page:
1 - 10 of 212