16:12 , Mar 14, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Tuberculosis (TB) Cell culture studies identified sansanmycin-based inhibitors of M. tuberculosis murX that could help treat TB. Chemical synthesis and testing in M. tuberculosis culture of analogs of the natural product sansanmycin identified three...
07:00 , Oct 13, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Mycobacterium tuberculosis decaprenyl-phosphate N-acetylglucosaminephosphotransferase (rfe; wecA); M. tuberculosis phospho-N-acetylmuramoyl-pentap

Infectious disease INDICATION: Tuberculosis In vitro and cell studies suggest muraymycin D1-based, dual inhibitors of Mycobacterium tuberculosis rfe and murX could help treat tuberculosis (TB). In in vitro enzymatic assays, the antibiotic muraymycin D1 and...