BioCentury | Jul 17, 2014
Distillery Therapeutics

Indication: Infectious disease

...of dprE1 that could help treat tuberculosis. In vitro, 4-aminoquinolone piperidine amides were reversible, noncovalent dprE1...
...had a minimum inhibitory concentration of 60 nM. Next steps could include optimizing the lead dprE1...
BioCentury | Jul 25, 2013
Distillery Therapeutics

Indication: Infectious disease

...Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Tuberculosis Mycobacterium tuberculosis decaprenylphosphoryl-b-d-ribose 2ʹ-oxidase (dprE1...
...M. tuberculosis molybdopterin biosynthesis protein (moeW) Mouse and cell culture studies suggest an inhibitor of dprE1...
...and without causing weight loss or other adverse effects. In a series of genetic studies, dprE1...
BioCentury | Jul 11, 2013
Targets & Mechanisms

Targeting TB persistence

...TCA1's targets as M. tuberculosis decaprenylphosphoryl-b-d-ribose 2ʹ-oxidase (dprE1) and M. tuberculosis molybdopterin biosynthesis protein (moeW). dprE1...
...and moeW plays a role in molybdenum cofactor biosynthesis. The team also found evidence that dprE1...
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