07:00 , Jul 17, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Tuberculosis Mycobacterium tuberculosis decaprenylphosphoryl-b-d-ribose 2-oxidase (dprE1) In vitro studies have identified 4-aminoquinolone piperidine amide-based inhibitors of dprE1 that could help treat tuberculosis. In vitro,...
07:00 , Jul 25, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Tuberculosis Mycobacterium tuberculosis decaprenylphosphoryl-b-d-ribose 2ʹ-oxidase (dprE1); M. tuberculosis molybdopterin biosynthesis protein (moeW) Mouse and cell culture studies suggest an inhibitor of dprE1 and moeW...
07:00 , Jul 11, 2013 |  BC Innovations  |  Targets & Mechanisms

Targeting TB persistence

A group of researchers from California and New York has identified a small molecule with activity against currently intractable nonreplicating stages and drug-resistant strains of Mycobacterium tuberculosis . 1 The compound, which works by blocking...