BioCentury | Nov 2, 2018
Company News

Takeda proposes divestment of Shire GI candidate, announces loans

...its overall revenues (see “Takeda Hits the Gas” ). SHP647 is a first-in-class molecule targeting mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1)...
...LSE:SHP; NASDAQ:SHPG), Dublin, Ireland Business: Gastrointestinal Jaime De Leon Entyvio, vedolizumab (MLN0002) SHP647, pf-00547659 Shire plc Takeda Pharmaceutical Co. Ltd. Integrin alpha(4)beta(7) Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1)...
BioCentury | Mar 31, 2018
Strategy

Refashioning Takeda

...only GI program in Shire’s pipeline, but it is a first-in-class molecule. The mAb targeting mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1)...
BioCentury | Aug 4, 2017
Company News

Shire evaluating neurology pipeline

...its acquisition of Dyax Corp. Shire in-licensed SHP647, anti-human mucosal addressin cell adhesion molecule 1 (MAdCAM-1...
BioCentury | Aug 3, 2017
Company News

Shire evaluating neurology pipeline

...its acquisition of Dyax Corp. Shire in-licensed SHP647, anti-human mucosal addressin cell adhesion molecule 1 (MAdCAM-1...
BioCentury | Nov 3, 2016
Targets & Mechanisms

Going against the gut

...efficient” at blocking the interaction between α4β7 on CD4 + T cells and its receptor MAdCAM-1...
...Calif. Takeda Pharmaceutical Co. Ltd. (Tokyo:4502), Osaka, Japan Targets and Compounds Integrin α4β7 MAdCAM-1 - Mucosal vascular addressin cell adhesion molecule 1...
BioCentury | Jun 20, 2016
Company News

Pfizer, Shire deal

...worldwide rights to Pfizer’s PF-00547659 . The anti-human mucosal addressin cell adhesion molecule 1 ( MAdCAM-1...
BioCentury | Jun 15, 2016
Company News

Shire licenses IBD biologic from Pfizer

...terms were not disclosed. The mAb targeting mucosal vascular addressing cell adhesion molecule 1 ( MAdCAM-1...
BioCentury | Dec 4, 2014
Strategy

Merck Encycles through Canada

...integrin a 4 b 7 , a protein expressed by lymphocytes that binds mucosal vascular addressin cell adhesion molecule 1 ( MAdCAM-1...
...to those for two antibodies-an anti-mouse integrin a 4 b 7 mAb and an anti-mouse Madcam-1...
BioCentury | Sep 18, 2014
Translation in Brief

Translational tidbits

...is marketed to treat rheumatoid arthritis (RA). The pharma also has the anti-human mucosal vascular addressin cell adhesion molecule 1 ( MADCAM-1...
BioCentury | Jan 30, 2014
Translation in Brief

Translational tidbits

...Amgen's AMG 181 , a mAb that prevents integrin α4b7 from binding to mucosal vascular addressin cell adhesion molecule 1 ( MAdCAM-1...
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