BioCentury | Jul 15, 2020
Product Development

INmune therapy shows promise in Alzheimer’s, but cognitive test still to come

...that gets excreted first in many inflammatory reactions.” Downstream, TNF prompts production of IL-1, IL-6, CCL2...
BioCentury | Jun 20, 2020
Translation in Brief

CAR Ts against senescent cells; plus NIH program for ALS, sex-dependent COVID-19 immune responses and more

CAR T liver fibrosis therapy Memorial Sloan Kettering Cancer Center researchers have generated CAR T cells against PLAUR, which is involved in extracellular matrix remodelling, that could eliminate pathologic senescent cells . Senescent cells have been...
BioCentury | Apr 15, 2020
Product Development

AZ targeting cytokine storms as ranks of repurposed agents for COVID-19 grow

...ventilation. Because Btk inhibition reduces the production of several cytokines including TNFα, IL-6, IL-10 and MCP-1...
...proteinase Btk - Bruton’s tyrosine kinase IL-6 - Interleukin-6 IL-10 - Interleukin-10 MCP-1 (CCL2) - Monocyte chemoattractant protein-1...
BioCentury | Dec 6, 2019
Targets & Mechanisms

A view of immune reprogramming from ASH

...mutations or tool compounds. A presentation from Zhejiang University School of Medicine shows the chemokine CCL2...
...1 (FLI1) JAK-1 - Janus kinase-1 (JAK-1) JAK-2 - Janus kinase-2 (JAK-2) MCP-1 (CCL2) - Monocyte chemoattractant protein-1...
BioCentury | Nov 14, 2019
Company News

Nov. 13 Company Quick Takes: FDA panel rebuffs Jardiance; plus Nucala, Cellular Biomedicine, BeiGene, Autolus and Noile-Immune

Panel rebuffs Jardiance for Type I diabetes FDA’s Endocrinologic and Metabolic Drugs Advisory Committee voted 14-2 Wednesday that available data do not support approval of Jardiance empagliflozin from Boehringer Ingelheim GmbH. The panel was asked...
BioCentury | Oct 8, 2019

Novel targets induce cardiomyocyte regeneration

DISEASE CATEGORY: Cardiovascular INDICATION: Myocardial infarction (MI) Gene therapies delivering CCL24 or IGF2BP3 could restore cardiac function following MI. RNA-seq analysis identified 874 genes including CCL24 and IGF2BP3 that were upregulated in mouse heart tissue...
BioCentury | Oct 3, 2019
Targets & Mechanisms

Stimulating heart regeneration following injury

A multi-omic study of regenerating neonatal hearts has uncovered novel therapeutic targets for cardiac injury post myocardial infarction. Study leader Eric Olson said the findings serve as a resource for understanding the DNA sequences and...
BioCentury | Aug 27, 2019
Company News

Aug. 27 Company Quick Takes: GSK licenses Ionis HBV program; plus Adaptimmune-Noile, Purdue, Presage-BMS, Kyowa, Alexion, Viela, Kintai, OncoNano

GSK opts into Ionis' HBV program Positive Phase II data prompted GlaxoSmithKline plc (LSE:GSK; NYSE:GSK) to exercise its option to license exclusive, worldwide rights to an antisense chronic HBV program from Ionis Pharmaceuticals Inc. (NASDAQ:IONS)....
BioCentury | Aug 21, 2019
Financial News

Oncorus raises $79.5M series B with eye on global development

Nearly half a dozen Korean investment groups joined Oncorus' $79.5 million series B round as part of the company's long-range plan to take its oncolytic virus technology global. Cowen Healthcare Investments and Perceptive Advisors led...
BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

New and emerging targets at AACR 2019 show cancer researchers are gaining granularity on how to manipulate the tumor microenvironment, a top priority goal for the field. The targets point to emerging strategies for modulating...
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