BC Innovations | Jul 18, 2019
Distillery Therapeutics

Inhibition of BACH1 or the genes it controls for metastatic lung cancer

DISEASE CATEGORY: Cancer INDICATION: Lung cancer Inhibiting the pro-metastatic transcription factor BACH1 or its gene targets MCT1, HMOX1, HK2 and GADPH could treat metastatic lung cancer. In patients with metastasized lung cancer, levels of BACH1...
BC Innovations | Sep 28, 2018
Targets & Mechanisms

Cell metabolism’s migration

As cancer metabolism undergoes a renaissance in the clinic, with compounds targeting growth factor and nutrient sensing pathways, basic research on metabolic processes in all cells is shining light on pathways that could yield new...
BC Week In Review | Jun 10, 2013
Clinical News

AZD3965: Phase I started

Cancer Research U.K. began a 2-part, open-label, dose-escalation, U.K. Phase I trial to evaluate 5, 10, 20 and 30 mg oral AZD3965 given once or twice daily in 28-day cycles for up to 6 cycles...
BC Innovations | Jul 26, 2012
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Amyotrophic lateral sclerosis (ALS) Monocarboxylate transporter 1 (MCT1) Mouse and patient sample studies suggest increasing MCT1 levels could help decrease neurodegeneration in ALS. In mice,...
BioCentury | Aug 15, 2011
Product Development

Powering down cancer

The cancer metabolism field has been heating up over the last five years, and now is beginning to produce some of the first data for compounds aimed at stunting aerobic glycolysis, the energy-generating process that...
BC Innovations | Dec 18, 2008
Targets & Mechanisms

Cancer's fuel duel

A team of Belgian and U.S. researchers has demonstrated that hypoxic tumor cells can be killed by targeting solute carrier family 16, member 1 (monocarboxylic acid transporter 1), a membrane lactate transporter protein expressed on...
BC Innovations | Dec 11, 2008
Distillery Therapeutics

This week in therapeutics

The Distillery: Therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (SLC16A1; MCT1) Cell culture and mouse studies suggest that inhibiting MCT1...
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