07:00 , May 19, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: MAP kinase 7 (MAPK7; BMK1; ERK-5); mitogen-activated protein kinase kinase kinase 2 (MAP3K2); WNK lysine deficient protein kinase 1 (WNK1; PPP1R16

Cancer INDICATION: Prostate cancer Patient sample, mouse and cell culture studies suggest inhibiting MAPK7 or the MAPK7 pathway components MAP3K2 and WNK1 could help treat prostate adenocarcinoma cancer harboring gain-of-function FOXF1 mutations. In tissue samples from patients...
07:00 , Jun 12, 2014 |  BC Innovations  |  Targets & Mechanisms

Putting SMYD3 on the MAP

Stanford University and GlaxoSmithKline plc researchers have uncovered the mechanism of action of SMYD3, a histone lysine methyltransferase overexpressed in many lung and pancreatic tumors.1 The surprise was that SMYD3 acts in the cytoplasm to...
07:00 , Apr 23, 2007 |  BioCentury  |  Tools & Techniques

High probability pathways

High probability pathways Pathway Genes in pathway (A) Pathway components [Ranking] (A) [5] Fibroblast growth factor (FGF) signaling MAP2K4; FGFR4; FGFR1; MAPK14; MAPK8; MAPK9; FGFR3; MAP3K6; MAP3K2; MAPK11; PRKCB1; RAF1; PRKCA; PRKCH; MAPK13; AKT3; PRKCE;...