BioCentury | Sep 27, 2019
Preclinical News

Sept. 26 Preclinical Quick Takes: $30M for new lung disease lab; plus AI-derived compounds from Auransa, Atomwise, and diabetes candidates

...published a Cell Metabolism study showing a small molecule predicted to bind the mitochondrial regulator MIRO1...
...muscle atrophy. Targets: CD126 - Interleukin-6 receptor; CNTF - Ciliary neurotrophic factor; MIRO1 (RHOT1) - Mitochondrial Rho GTPase 1 BioCentury...
...of Medical Research Bayer AG Brigham and Women's Hospital Massachusetts General Hospital Ciliary neurotrophic factor (CNTF) receptor Interleukin-6 (IL-6) receptor (CD126) Mitochondrial Rho GTPase 1 (MIRO1) (RHOT1) SymbioCellTech...
BioCentury | Sep 20, 2018
Distillery Therapeutics

Neurology; ophthalmic disease

...INDICATION: Parkinson’s disease (PD); neurology; blindness Fruit fly studies suggest inhibiting ITPR, VDAC1, MCU, MIRO1 and/or...
...and blindness. In a Drosophila model of PD, knockdown of ITPR or MCU, or both MIRO1...
...1,4,5-triphosphate receptors (ITPR; IP3R); voltage-dependent anion channel 1 (VDAC1); mitochondrial calcium uniporter (MCU); mitochondrial Rho GTPase 1 (MIRO1; RHOT1...
BioCentury | Oct 19, 2017
Translation in Brief

Go/No-Go decider

...that control the motility of mitochondria along microtubules." Altieri pointed to Mitochondrial Rho GTPase 1 ( MIRO1 ; RHOT1...
BioCentury | Sep 18, 2014
Distillery Techniques

Technology: Disease models

...of motor neuron disease Miro1-deficient mice could be useful as models of motor neuron diseases. Miro1...
...brain stem cranial motor neurons and developed impairments in neural respiratory control. Mice with neuron-specific Miro1...
...had a disease phenotype that mimicked symptoms in patients with upper motor neuron disease. The Miro1-deficient...
BioCentury | Oct 6, 2008
Clinical News

Neuropad regulatory update

Ark said it had received reimbursement approval from the U.K.'s National Health Service (NHS) Business Services Authority for its Neuropad to detect early-stage diabetic foot syndrome. Following its listing in the Drug Tariff, Ark will...
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