BioCentury | May 20, 2019
Distillery Therapeutics

The OXPHOS complex I inhibitor IACS-010759 for mantle cell and B cell lymphoma

DISEASE CATEGORY: Cancer INDICATION: Mantle cell lymphoma (MCL); B cell lymphoma Patient sample, cell culture and mouse studies identified an OXPHOS complex I inhibitor that could help treat MCL and B cell lymphoma that are...
BioCentury | May 8, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: April 2019

...Intelligence; BioCentury Archives Indication Target Description Company or Institution Notes Therapeutic targets Cancer Brain cancer Mitochondrial oxidative phosphorylation complex V (OXPHOS complex V)...
BioCentury | Apr 30, 2019
Distillery Therapeutics

OXPHOS complex V inhibitor to treat glioblastoma

...could include testing the compound in combination with other drugs in the glioblastoma models. TARGET/MARKER/PATHWAY: Mitochondrial oxidative phosphorylation complex V (OXPHOS complex V)...
...Parada, Memorial Sloan Kettering Cancer Center, New York, N.Y. email: paradal@mskcc.org Claire Quang Memorial Sloan Kettering Cancer Center Mitochondrial oxidative phosphorylation complex V (OXPHOS complex V) Brain...
BioCentury | Jan 16, 2019
Distillery Therapeutics

Cancer

INDICATION: Renal cancer; lung cancer Cell culture and mouse studies suggest inhibiting PGD alone or in combination with OXPHOS complex I inhibition could help treat renal cell carcinoma (RCC) or non-small cell lung cancer (NSCLC),...
BioCentury | Nov 3, 2017
Clinical News

ImmunoMet starts Phase I of IM156 for solid tumors

ImmunoMet Therapeutics Inc. (Houston, Texas) began a Phase I trial of IM156 to treat solid tumors in up to 36 patients. The primary endpoint is to determine the maximum tolerated dose (MTD) and recommended Phase...
BioCentury | Jun 16, 2017
Emerging Company Profile

Metabolic regulation

ImmunoMet Therapeutics Inc. is developing a portfolio of biguanide derivatives that have the anticancer properties of metformin but are better optimized for the indication. Some starve drug-resistant cancers by blocking a metabolic pathway they rely...
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