...and colleagues showed that a small molecule construct designed to degrade the precursor of oncogenic miR-21...
...miR-21 - MicroRNA-21 miR-210 - MicroRNA-210 miR-515 - MicroRNA-515 Lauren Martz, Senior Editor Scripps Research Institute Expansion Therapeutics Inc. MicroRNA-21...
...MicroRNA-21 miR-210 - MicroRNA-210 miR-515 - MicroRNA-515 Lauren Martz, Senior Editor Scripps Research Institute Expansion Therapeutics Inc. MicroRNA-21 (miR-21) Triple-negative...

...and could become the first approved therapy for the indication. At least one other therapy, MiR-21...
...and Sanofi (Euronext:SAN; NASDAQ:SNY), is in the clinic for Alport syndrome. The antisense oligonucleotide against miR-21...
...close, the company proposed to sell 2 million shares in a follow-on. Targets: miR-21 - MicroRNA-21...

...three hits -- the generic topoisomerase inhibitors doxorubicin, epirubicin and mitoxantrone -- that decreased oncogenic miR-21...
...a human TNBC cell line. Also in the cell line, mitoxantrone blocked invasiveness mediated by miR-21...
...rare genetic disorders (see “Expanding Small Molecule Horizons” ). Jennie Walters, Staff Writer The Scripps Research Institute MicroRNA-21 (miR-21) MicroRNA-96...

...curative NSCLC surgery. While tumors from both groups had 18 differentially expressed miRNAs -- including miR-21...
...Cancer Research (2017) Jennie Walters, Staff Writer National Institutes of Health Dual specificity phosphatase 7 (DUSP7) (MKPX) MicroRNA-191 (miR-191) MicroRNA-21 (miR-21) Lung...

...renal biopsy study are expected by year end. RG-012 is an antisense oligonucleotide inhibiting microRNA-21 (miR-21...
...million. Regulus Therapeutics Inc. (NASDAQ:RGLS), San Diego, Calif. Business: Cancer, Infectious, Hepatic Chris Lieu RG-012 Regulus Therapeutics Inc. MicroRNA-21 (miR-21...

...Diego, Calif. Product: miR-21 (anti-miR-21) ( RG-012 ) (formerly antagomir-21) Business: Renal Molecular target: MicroRNA-21 (miR-21...
...RG-012 ) (formerly antagomir-21) Business: Renal Molecular target: MicroRNA-21 (miR-21) Description: Antisense oligonucleotide inhibiting miR-21...
...mid-2017); Phase I/II data (year end 2017); interim Phase II data (mid-2018) Julian Zhu anti-miR-21 RG-012 Regulus Therapeutics Inc. MicroRNA-21 (miR-21...

...fibrosarcoma, IV injection of perfluorocarbon nanodroplets followed by tumor-directed ultrasonication increased serum levels of microRNA-21-5p (miR-21-5p...
...doi:10.1158/0008-5472.CAN-15-3231 CONTACT: Roger J. Zemp, University of Alberta, Edmonton, Alberta email: rzemp@ualberta.ca Mark Zipkin University of Alberta MicroRNA-21-5p (miR-21-5p...

...expression could help treat ovarian cancer. In tissue samples from ovarian cancer patients, levels of miR-21...
...miR-21 expression in ovarian cancer cells. TARGET/MARKER/PATHWAY: Apoptotic peptidase activating factor 1 (APAF1) ; microRNA-21 (miR-21...

...Biomarkers SOX2 microRNA-21 (miR-21) SRY (sex determining region Y)-box 2 (SOX2) University of Texas MD Anderson...

...developing microRNA-based therapies for cancer. Its lead candidate, lumiralin ( AM-21 ), an anti- microRNA-21 (miR-21...