BioCentury | Jan 21, 2020
Tools & Techniques

Disney lab uncovers another RNA-binding small molecule for triple-negative breast cancer

...and colleagues showed that a small molecule construct designed to degrade the precursor of oncogenic miR-21...
...miR-21 - MicroRNA-21 miR-210 - MicroRNA-210 miR-515 - MicroRNA-515 Lauren Martz, Senior Editor Scripps Research Institute Expansion Therapeutics Inc. MicroRNA-21...
...MicroRNA-21 miR-210 - MicroRNA-210 miR-515 - MicroRNA-515 Lauren Martz, Senior Editor Scripps Research Institute Expansion Therapeutics Inc. MicroRNA-21 (miR-21) Triple-negative...
BioCentury | Nov 13, 2019
Clinical News

Bardoxolone data set Reata up to advance second compound toward registration

...and could become the first approved therapy for the indication. At least one other therapy, MiR-21...
...and Sanofi (Euronext:SAN; NASDAQ:SNY), is in the clinic for Alport syndrome. The antisense oligonucleotide against miR-21...
...close, the company proposed to sell 2 million shares in a follow-on. Targets: miR-21 - MicroRNA-21...
BioCentury | Jul 11, 2018
Translation in Brief

The RNA Renaissance continues

...three hits -- the generic topoisomerase inhibitors doxorubicin, epirubicin and mitoxantrone -- that decreased oncogenic miR-21...
...a human TNBC cell line. Also in the cell line, mitoxantrone blocked invasiveness mediated by miR-21...
...rare genetic disorders (see “Expanding Small Molecule Horizons” ). Jennie Walters, Staff Writer The Scripps Research Institute MicroRNA-21 (miR-21) MicroRNA-96...
BioCentury | Feb 8, 2018
Translation in Brief

Diverging pathways

...curative NSCLC surgery. While tumors from both groups had 18 differentially expressed miRNAs -- including miR-21...
...Cancer Research (2017) Jennie Walters, Staff Writer National Institutes of Health Dual specificity phosphatase 7 (DUSP7) (MKPX) MicroRNA-191 (miR-191) MicroRNA-21 (miR-21) Lung...
BioCentury | May 12, 2017
Company News

Regulus reducing headcount by 30%

...renal biopsy study are expected by year end. RG-012 is an antisense oligonucleotide inhibiting microRNA-21 (miR-21...
...million. Regulus Therapeutics Inc. (NASDAQ:RGLS), San Diego, Calif. Business: Cancer, Infectious, Hepatic Chris Lieu RG-012 Regulus Therapeutics Inc. MicroRNA-21 (miR-21...
BioCentury | May 12, 2017
Clinical News

Regulus reports Phase I data for antisense therapy RG-012

...Diego, Calif. Product: miR-21 (anti-miR-21) ( RG-012 ) (formerly antagomir-21) Business: Renal Molecular target: MicroRNA-21 (miR-21...
...RG-012 ) (formerly antagomir-21) Business: Renal Molecular target: MicroRNA-21 (miR-21) Description: Antisense oligonucleotide inhibiting miR-21...
...mid-2017); Phase I/II data (year end 2017); interim Phase II data (mid-2018) Julian Zhu anti-miR-21 RG-012 Regulus Therapeutics Inc. MicroRNA-21 (miR-21...
BioCentury | Feb 8, 2017
Distillery Techniques

Assays and screens

...fibrosarcoma, IV injection of perfluorocarbon nanodroplets followed by tumor-directed ultrasonication increased serum levels of microRNA-21-5p (miR-21-5p...
...doi:10.1158/0008-5472.CAN-15-3231 CONTACT: Roger J. Zemp, University of Alberta, Edmonton, Alberta email: rzemp@ualberta.ca Mark Zipkin University of Alberta MicroRNA-21-5p (miR-21-5p...
BioCentury | Apr 7, 2016
Distillery Therapeutics

Therapeutics: Apoptotic peptidase activating factor 1 (APAF1); microRNA-21 (miR-21)

...expression could help treat ovarian cancer. In tissue samples from ovarian cancer patients, levels of miR-21...
...miR-21 expression in ovarian cancer cells. TARGET/MARKER/PATHWAY: Apoptotic peptidase activating factor 1 (APAF1) ; microRNA-21 (miR-21...
BioCentury | Jan 14, 2016
Distillery Techniques

Techniques: Levels of microRNA-21 (miR-21) and SRY (sex determining region Y)-box 2 (SOX2) to predict outcomes in glioblastoma multiforme (GBM)

...Biomarkers SOX2 microRNA-21 (miR-21) SRY (sex determining region Y)-box 2 (SOX2) University of Texas MD Anderson...
BioCentury | Jan 4, 2016
Company News

Microlin Bio, American Boarding deal

...developing microRNA-based therapies for cancer. Its lead candidate, lumiralin ( AM-21 ), an anti- microRNA-21 (miR-21...
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