BC Innovations | Apr 11, 2017
Distillery Therapeutics


INDICATION: Dermatitis Mouse studies suggest inhibiting CLEC4E could help treat allergic dermatitis. In mouse models of irritant-induced allergic dermatitis, knockout of CLEC4E decreased skin inflammation and levels of inflammatory cytokines at the irritation site compared...
BC Innovations | Dec 20, 2016
Distillery Therapeutics

Infectious disease

INDICATION: Leishmaniasis Mouse studies suggest inhibiting CLEC4E could help treat leishmaniasis. In mice infected with Leishmania major via ear injection, knockout of CLEC4E decreased parasite load and dermal lesions at injection site, and increased the...
BC Innovations | Oct 2, 2008
Targets & Mechanisms

Autoimmunity Gets Mincle and Dimed

Researchers at the RIKEN Research Center for Allergy and Immunology have identified MINCLE as a receptor that triggers neutrophil recruitment and secretion of proinflammatory cytokines in response to necrotic cells derived from injured tissue. 1...
BC Innovations | Sep 25, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker /pathway Summary Licensing status Publication and contact information Autoimmune disease Autoimmune C-type lectin domain family 4, member E (CLEC4E; MINCLE) Studies in mice suggest that inhibiting MINCLE may be...
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