BC Innovations | Jun 19, 2019
Distillery Therapeutics

Inhibiting miR-181a and miR-181b could treat obesity

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Obesity Inhibition of miR-181a and miR-181b or treatment with indole -- a negative regulator of the two microRNAs -- could help treat obesity. Expression of miR-181a2 and miR-181b2 in white adipose...
BC Innovations | Apr 25, 2019
Emerging Company Profile

miR Scientific: spotting aggression with RNA in urine

miR has paired its panel of urine-based RNAs with a statistical algorithm for accurate diagnosis of aggressive bladder and prostate cancers, sparing patients with lower-grade tumors from invasive biopsies and unnecessary drug treatments. The company's...
BC Innovations | Nov 7, 2018
Translation in Brief

Expanding the reach of plant exosomes

A University of Louisville team has shown how plant-derived exosomes could mobilize the gut microbiome against colitis, broadening the range of potential indications for the technology beyond those the university already has in Phase I...
BC Innovations | Nov 6, 2018
Distillery Techniques

Assays and screens

TECHNOLOGY: Diagnostic assays Serum levels of two 10-miRNA panels could help diagnose ovarian tumors. In a cohort of 333 patients with ovarian cancers, 66 with borderline ovarian tumors, 29 with benign ovarian tumors, 859 with...
BC Week In Review | Sep 7, 2018
Financial News

Non-coding RNA company Twentyeight-Seven debuts with $65M

Twentyeight-Seven Therapeutics Inc. (Cambridge, Mass.) raised $65 million on Sept. 6 in a series A round co-led by MPM Capital and Novartis Venture Fund. Johnson & Johnson Innovation-JJDC Inc., Vertex Ventures HC, Longwood Fund and...
BC Extra | Sep 6, 2018
Financial News

Non-coding RNA company Twentyeight-Seven debuts with $65M

Twentyeight-Seven Therapeutics Inc. (Cambridge, Mass.) raised $65 million in a series A co-led by MPM Capital and Novartis Venture Fund. Johnson & Johnson Innovation-JJDC Inc., Vertex Ventures HC, Longwood Fund and Astellas Venture Management also...
BC Innovations | Aug 17, 2018
Targets & Mechanisms

RNA party

A study in Cell has uncovered a brain regulatory network involving a circular RNA, a long non-coding RNA and two microRNAs, and could provide some much needed insights in a field where finding links to...
BC Innovations | Jul 11, 2018
Translation in Brief

The RNA Renaissance continues

Two papers from Matthew Disney’s lab at The Scripps Research Institute herald a pair of RNA-related discoveries: a method for engineering small molecules that target and cleave oncogenic microRNAs, and a platform that identified RNA-targeting...
BC Extra | May 24, 2018
Preclinical News

miRNA-targeted circular single-stranded DNA to treat cancer

A Nankai University-based team developed a small circular single-stranded DNA molecule that inhibits cancer growth in cells and mice by sequestering microRNAs (miRNAs) that silence tumor suppressor genes. Preclinical deals in nucleic acid modalities over...
BC Innovations | May 23, 2018
Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Cell-free assays; gene profiling A method for profiling miRNAs in extracellular vesicles could be used to identify diagnostic markers for pancreatic and other cancers. The method involves linking magnetic anti-biotin microbeads to biotinylated antibodies...
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