BioCentury | Apr 13, 2018
Targets & Mechanisms

Hello RNA

BioCentury’s analysis of new and emerging targets presented at this year’s AACR meeting reveals a surge in activity in non-coding RNAs, as researchers continue to expand target space. The results also reflect the ongoing high...
BioCentury | Jun 30, 2016
Distillery Techniques

Techniques: A 15-microRNA (miRNA) signature to predict survival in patients with colon, pancreatic and stomach cancers

Biomarkers TECHNOLOGY: Gene profiling A 15-microRNA signature associated with high doublecortin-like kinase 1 (DCLK1) activity could help predict survival in colon, pancreatic and stomach cancers. In colon, esophageal, pancreatic, rectal and stomach tumor samples from...
BioCentury | Feb 18, 2016
Distillery Techniques

Techniques: Ester-based dendrimers for non-toxic delivery of RNA therapies to the liver

Drug delivery TECHNOLOGY: Nanoparticles Ester-based dendrimers could deliver siRNA and microRNA therapies to the liver with minimal hepatic toxicity. Chemical synthesis, in vitro and in vivo testing of biodegradable 2-(acryloyloxy)ethylmethacrylate-based dendrimers identified the combination of...
BioCentury | Dec 18, 2014
Distillery Techniques

Techniques: MicroRNA let-7c (MIRLET7C; let-7c), microRNA-99a (miR-99a) and microRNA-125b (miR-125b) as prognostic markers of luminal breast cancer

Bio Markers TECHNOLOGY: Markers Studies in patient samples and cell culture suggest let-7c , miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor-positive luminal breast cancers. MicroRNA profiling showed that levels of...
BioCentury | Apr 24, 2014
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain MicroRNA let-7b (MIRLET7B; LET-7B); toll-like receptor 7 (TLR7); transient receptor potential A1 (TrpA1) Cell culture and mouse studies suggest inhibiting extracellular MIRLET7B could help...
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