BC Innovations | Jul 11, 2018
Translation in Brief

The RNA Renaissance continues

Two papers from Matthew Disney’s lab at The Scripps Research Institute herald a pair of RNA-related discoveries: a method for engineering small molecules that target and cleave oncogenic microRNAs, and a platform that identified RNA-targeting...
BC Innovations | Jun 5, 2018
Distillery Therapeutics

Cancer

INDICATION: Breast cancer An RNA-targeting small molecule that cleaves miR-96 could help treat triple-negative breast cancer (TNBC). The compound consists of a short poly(A) oligionucleotide linked to a small molecule that selectively binds the oncogenic...
BC Innovations | Jun 15, 2017
Translation in Brief

MicroRNA's big role in pain

In Science this month, Karolinska Institute researchers uncovered the mechanism of a microRNA complex in pain and showed it functions in a neuronal population not currently targeted by any therapeutics. The authors believe the neurons...
BC Innovations | Oct 20, 2016
Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell and mouse studies suggest miR-96 or miR-182 could help treat metastatic breast cancer. In human and mouse breast cancer cell lines, a plasmid encoding miR-96 or miR-182 decreased migration and invasiveness...
BC Innovations | May 19, 2016
Distillery Therapeutics

Therapeutics: MicroRNA-96 (miR-96)

Cancer INDICATION: Breast cancer In vitro studies identified an miR-96 inhibitor that could help treat breast cancer. In silico drug design and optimization of a benzimidazole-based miR-96 inhibitor identified a heterodimer consisting of the inhibitor...
BC Innovations | Apr 10, 2014
Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Small molecule inhibitors of microRNA processing An in vitro screening system could be used to identify small molecule inhibitors of miRNAs. Structural calculations of human...
BC Innovations | Apr 30, 2009
Cover Story

miRNAs sounding better

Hearing loss is a field that has been totally refractory to drug treatment. Now, British and Spanish researchers have converged on microRNA-96, or elements downstream of it, as a potential therapeutic target for treating age-related...
BC Innovations | Apr 23, 2009
Distillery Therapeutics

Indication: Other

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Other Hearing loss MicroRNA-96 (miRNA-96) Studies in mice and in humans identified mutations in miRNA-96 that could be useful predictors of susceptibility...
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