18:54 , May 30, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Solid tumors Cell culture and mouse studies suggest a circular single-stranded DNA (CSSD) with four miR-9 binding sites could help treat breast, liver, lung and other solid tumors. The CSSD was generated by linking...
21:28 , May 24, 2018 |  BC Extra  |  Preclinical News

miRNA-targeted circular single-stranded DNA to treat cancer

A Nankai University-based team developed a small circular single-stranded DNA molecule that inhibits cancer growth in cells and mice by sequestering microRNAs (miRNAs) that silence tumor suppressor genes. Preclinical deals in nucleic acid modalities over...
19:44 , Oct 3, 2017 |  BC Innovations  |  Distillery Therapeutics

Pulmonary

INDICATION: Cystic fibrosis (CF) Cell culture, patient sample and mouse studies suggest inhibiting the interaction of miR-9 with its negative regulator ANO1 could help treat mucus accumulation in CF. In bronchial epithelial cells from patients,...
07:00 , Aug 11, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: MicroRNA-9 (miR-9); miR-200c

Cancer INDICATION: Breast cancer Patient sample and mouse studies suggest inhibiting miR-9 or promoting miR-200c expression could help treat triple-negative breast cancer (TNBC). In patient samples, high tumor miR-9 levels correlated with poor metastasis-free survival...
08:00 , Nov 20, 2014 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Direct reprogramming of human fibroblasts to striatal medium spiny neurons (MSNs) Direct reprogramming of human fibroblasts to human striatal neurons could help generate new cellular...