BioCentury | Oct 7, 2010
Distillery Therapeutics

Indication: Cancer

...suggest that antagonizing miR-380-5p could help treat neuroblastoma. About 76% of primary neuroblastoma samples showed miR-380-5p...
...expression in normal brain tissue. In a mouse neuroblastoma model, twice-weekly injections of chemically modified anti-miR-380-5p...
...with injection of control oligonucleotides (p=0.01). Next steps include identifying other tumors in which antagonizing miR-380-5p...
BioCentury | Oct 7, 2010
Targets & Mechanisms

An miRNA boost for p53

...the Oncogenomics Laboratory at the Queensland Institute of Medical Research . Initially, the group identified miR-380-5p...
...protein homolog (MDM2; HDM2 ) pathway. Of 205 primary patient neuroblastoma samples, 203 had detectable miR-380-5p...
...Goga agreed that miR-380-5p could be regulating other proteins but said the antitumor effect from miR-380-5p...
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